0001410578-22-002665 | 6-K | XBRL Viewer | Quoin Pharmaceuticals LTD

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Document and Entity Information	6 Months Ended
Document and Entity Information	Jun. 30, 2022
Document and Entity Information [Abstract]
Entity Registrant Name	QUOIN PHARMACEUTICALS LTD.
Document Type	6-K
Current Fiscal Year End Date	--12-31
Amendment Flag	false
Entity Central Index Key	0001671502
Document Period End Date	Jun. 30, 2022
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q2
Entity File Number	000-00000

Consolidated Balance Sheets (Unaudited) - USD ($)	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash	$ 2,687,847	$ 7,482,773
Prepaid expenses	826,803	1,015,474
Total current assets	3,514,650	8,498,247
Intangible assets, net	756,583	808,604
Other Assets	50,000	50,000
Total assets	4,321,233	9,356,851
Current liabilities:
Accounts payable	768,670	923,239
Accrued expenses	1,864,794	1,685,409
Accrued license acquisition		250,000
Accrued interest	432,170	743,840
Due to officers - short term	600,000	600,000
Warrant liability		373,599
Total current liabilities	3,665,634	4,576,087
Due to officers - long term	3,823,733	4,123,732
Total liabilities	7,489,367	8,699,819
Commitments and contingencies
Shareholders' (deficit) equity:
Ordinary shares, no par value per share, 50,000,000,000 ordinary shares authorized - 5,065,154,799 (1,013,031 ADSs) ordinary shares issued and outstanding at June 30, 2022 and 3,354,650,799 (670,930 ADSs) at December 31, 2021	0	0
Treasury Stock, 2,641,693 ordinary shares	(2,932,000)	(2,932,000)
Additional paid in capital	32,184,820	31,659,017
Accumulated deficit	(32,420,954)	(28,069,985)
Total shareholders' (deficit) equity	(3,168,134)	657,032
Total liabilities and shareholders' equity	$ 4,321,233	$ 9,356,851

Consolidated Balance Sheets (Unaudited) (Parenthetical) - $ / shares	Jun. 30, 2022	Dec. 31, 2021
Ordinary shares, par value	$ 0	$ 0
Ordinary shares, shares authorized	50,000,000,000	50,000,000,000
Ordinary shares, shares issued	5,065,154,799	3,354,650,799
Ordinary shares, shares outstanding	5,065,154,799	3,354,650,799
Treasury Stock, ordinary shares	2,641,693	2,641,693
ADS
Ordinary shares, shares issued	1,013,031	670,930
Ordinary shares, shares outstanding	1,013,031	670,930

Consolidated Statements of Operations (Unaudited) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Operating expenses
General and administrative	$ 1,941,473	$ 737,610	$ 3,529,943	$ 1,482,583
Research and development	726,694	239,280	1,314,263	296,068
Total operating expenses	2,668,167	976,890	4,844,206	1,778,651
Other expenses (income)
Forgiveness of trade payable			(416,000)
Fair value adjustment to convertible notes payable		750,000		1,250,000
Change in fair value of warrant liability		2,223,139	(77,237)	4,669,652
Financing expense		185,000		275,000
Interest expense		202,514		268,111
Total other expense (income)		3,360,653	(493,237)	6,462,763
Net loss	$ (2,668,167)	$ (4,337,543)	$ (4,350,969)	$ (8,241,414)
ADS
Loss per ADS
Basic	$ (3.24)	$ (18.05)	$ (5.83)	$ (34.30)
Fully-diluted	$ (3.24)	$ (18.05)	$ (5.83)	$ (34.30)
Weighted average number of ADSs outstanding
Basic	822,877	240,292	746,903	240,292
Fully-diluted	822,877	240,292	746,903	240,292

Consolidated Statements of Shareholders' Deficit (Unaudited) - USD ($)	Ordinary Shares	Treasury Stock	Additional paid in Capital	Accumulated Deficit	ADS	Total
Balance at beginning of year at Dec. 31, 2020			$ 100	$ (6,607,397)		$ (6,607,297)
Balance at beginning of year (in shares) at Dec. 31, 2020	1,201,460,800				240,292
Net loss				(3,903,871)		(3,903,871)
Balance at end of year at Mar. 31, 2021			100	(10,511,268)		(10,511,168)
Balance at ending of year (in shares) at Mar. 31, 2021	1,201,460,800				240,292
Balance at beginning of year at Dec. 31, 2020			100	(6,607,397)		(6,607,297)
Balance at beginning of year (in shares) at Dec. 31, 2020	1,201,460,800				240,292
Net loss						(8,241,414)
Balance at end of year at Jun. 30, 2021	$ 1,201,460,800		100	(14,848,811)		(14,848,711)
Balance at ending of year (in shares) at Jun. 30, 2021					240,292
Balance at beginning of year at Mar. 31, 2021			100	(10,511,268)		(10,511,168)
Balance at beginning of year (in shares) at Mar. 31, 2021	1,201,460,800				240,292
Net loss				(4,337,543)		(4,337,543)
Balance at end of year at Jun. 30, 2021	$ 1,201,460,800		100	(14,848,811)		(14,848,711)
Balance at ending of year (in shares) at Jun. 30, 2021					240,292
Balance at beginning of year at Dec. 31, 2021	$ 3,354,650,799	$ (2,932,000)	31,659,017	(28,069,985)		$ 657,032
Balance at beginning of year (in shares) at Dec. 31, 2021					670,930	3,354,650,799
Net loss				(1,682,802)		$ (1,682,802)
Cashless warrant exercises (in shares)	3,200				1
Reclassification of warrant liability upon issuance of Exchange warrant			296,362			296,362
Balance at end of year at Mar. 31, 2022	$ 3,354,653,999	(2,932,000)	31,955,379	(29,752,787)		(729,408)
Balance at ending of year (in shares) at Mar. 31, 2022					670,931
Balance at beginning of year at Dec. 31, 2021	3,354,650,799	(2,932,000)	31,659,017	(28,069,985)		$ 657,032
Balance at beginning of year (in shares) at Dec. 31, 2021					670,930	3,354,650,799
Net loss						$ (4,350,969)
Balance at end of year at Jun. 30, 2022	5,065,154,799	(2,932,000)	32,184,820	(32,420,954)		$ (3,168,134)
Balance at ending of year (in shares) at Jun. 30, 2022					1,013,031	5,065,154,799
Balance at beginning of year at Mar. 31, 2022	$ 3,354,653,999	(2,932,000)	31,955,379	(29,752,787)		$ (729,408)
Balance at beginning of year (in shares) at Mar. 31, 2022					670,931
Net loss				(2,668,167)		(2,668,167)
Stock based compensation			229,441			229,441
Cashless warrant exercises (in shares)	1,710,500,800				342,100
Balance at end of year at Jun. 30, 2022	$ 5,065,154,799	$ (2,932,000)	$ 32,184,820	$ (32,420,954)		$ (3,168,134)
Balance at ending of year (in shares) at Jun. 30, 2022					1,013,031	5,065,154,799

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

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- Definition

Total of all stockholders' equity (deficit) items, net of receivables from officers, directors, owners, and affiliates of the entity which are attributable to the parent. The amount of the economic entity's stockholders' equity attributable to the parent excludes the amount of stockholders' equity which is allocable to that ownership interest in subsidiary equity which is not attributable to the parent (noncontrolling interest, minority interest). This excludes temporary equity and is sometimes called permanent equity.

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Consolidated Statements of Cash Flows (unaudited) - USD ($)	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows provided by (used in) operating activities
Net loss	$ (4,350,969)	$ (8,241,414)
Fair value adjustment to convertible notes payable		1,250,000
Change in fair value of warrant liability	(77,237)	4,669,652
Stock based compensation expense	229,441
Forgiveness of trade payable	(416,000)
Financing expense		275,000
Amortization of intangibles	52,021	52,022
Changes in assets and liabilities:
Increase in accounts payable and accrued expenses	440,817	141,395
(Decrease) Increase in accrued interest	(311,670)	268,111
(Decrease) Increase in prepaid expenses	188,671	(48,510)
Net cash used in operating activities	(4,244,926)	(1,633,744)
Cash flows used in investing activities
Payment for license acquisition	(250,000)	(267,500)
Net cash used in investing activities	(250,000)	(267,500)
Cash flows provided by (used in) financing activities:
Decrease in deferred offering costs		(111,808)
Deferred loan costs		(50,000)
Increase in due to officers		139,285
Payments of amounts due to officers	(300,000)	(154,466)
Proceeds from issuance of "Bridge Notes", net		3,475,000
Net cash (used in) provided by financing activities	(300,000)	3,298,011
Net change in cash	(4,794,926)	1,396,767
Cash - beginning of period	7,482,773	323,832
Cash - end of period	2,687,847	$ 1,720,382
Supplemental information:
Reclassification of warrant liability to equity upon issuance of "Exchange Warrants"	$ 296,362

ORGANIZATION AND BUSINESS

6 Months Ended

Jun. 30, 2022

ORGANIZATION AND BUSINESS

ORGANIZATION, BUSINESS AND BASIS OF PRESENTATION

NOTE 1 – ORGANIZATION AND BUSINESS

Quoin Pharmaceuticals Ltd. (“Quoin Ltd.,”the “Company,” “we,” “us,” or “our”), formerly known as Cellect Biotechnology Ltd. (“Cellect”), is the holding company for Quoin Pharmaceuticals, Inc., a Delaware corporation (“Quoin Inc.”). On October 28, 2021, Cellect completed the business combination with Quoin Inc., in accordance with the terms of the Agreement and Plan of Merger and Reorganization, dated as of March 24, 2021 (the “Merger Agreement”), by and among Cellect, Quoin Inc. and CellMSC, Inc., a Delaware corporation and wholly-owned subsidiary of Cellect (“Merger Sub”), pursuant to which Merger Sub merged with and into Quoin Inc., with Quoin Inc. surviving as a wholly-owned subsidiary of Cellect (the “Merger”). Immediately after completion of the Merger, Cellect changed its name to “Quoin Pharmaceuticals Ltd.” The Company has accounted for the transaction as a reverse recapitalization with Quoin Inc. as the accounting acquirer. Because Quoin Inc. is the accounting acquirer, its historical financial statements became the Company’s historical financial statements and such assets and liabilities continued to be recorded at their historical carrying values. The impact of the recapitalization has been retroactively applied to all periods presented. Immediately after the closing of the Merger, there were approximately 8,386,627 American Depositary Shares (“ADSs”) issued and outstanding, with one ADS representing 5,000 ordinary shares of the Company. The former holders of common stock of Quoin Inc. (including shares delivered to Altium Growth Fund, LP (the “Investor” or “Altium”) and the escrow account for the Investor) owned, in the aggregate, approximately 88% of the ordinary shares, with Cellect’s shareholders immediately prior to the Merger owning approximately 12% of ordinary shares upon the closing of the transaction.

Effective August 1, 2022, the ratio of ADS evidencing ordinary shares changed from 1 ADS representing four hundred (400) ordinary shares to 1 ADS representing five thousand (5,000) ordinary shares, which resulted in a one for 12.5 reverse split of the issued and outstanding ADSs (the “Ratio Change”). All ADSs and related option and warrant information presented in these financial statements and accompanying footnotes has been retroactively adjusted to reflect the reduced number of ADSs resulting from the Ratio Change.

Quoin Inc. was incorporated in Delaware on March 5, 2018. Quoin Inc. is a specialty pharmaceutical company focused on developing and commercializing therapeutic products that treat rare and orphan diseases. The first lead product is QRX003, a once daily, topical lotion comprised of a broad-spectrum serine protease inhibitor, formulated with the proprietary Invisicare® technology, to treat Netherton Syndrome (NS). QRX003, is currently in clinical development in the United States under an open IND application with the FDA. The ongoing study is a randomized, double blinded assessment of two different doses of QRX003 versus a placebo vehicle in NS patients. The trial will be conducted in up to six clinical sites in the United States. The first clinical site was open in July 2022. The opening of additional sites is in process, as is patient recruitment into the study. In addition, the Company. intends to pursue the clinical development of QRX003 in additional rare dermatological diseases, including Peeling Skin Syndrome, SAM Syndrome and Palmoplantar Keratoderma. To date, no products have been commercialized and revenue has not been generated.

On October 28, 2021, Cellect sold the entire share capital of its subsidiary, Cellect Biotherapeutics Ltd., which essentially included all of Cellect’s then existing net assets, to EnCellX Inc. (“EnCellX”), a newly formed U.S. privately held company based in San Diego, CA (the “Share Transfer”), pursuant to an Amended and Restated Share Transfer Agreement. Quoin Ltd. has no interests in EnCellX subsequent to the closing of the Merger. See Note 14.

On October 28, 2021, the Company completed the private placement transaction with the Investor for an aggregate purchase price of approximately $17 million (comprised of the set off of approximately $5 million of senior secured notes issued in connection with the bridge loan that the Investor previously made to Quoin Inc. and approximately $12 million in cash from the Investor) (the “Primary Financing”). See Note 5.

LIQUIDITY RISKS AND UNCERTAINTIES

6 Months Ended

Jun. 30, 2022

LIQUIDITY RISKS AND UNCERTAINTIES

LIQUIDITY RISKS AND UNCERTAINTIES

NOTE 2 - LIQUIDITY RISKS AND UNCERTAINTIES

The Company has incurred net losses every year since inception and had an accumulated deficit of approximately $32.4 million at June 30, 2022. The Company funded its operations through the issuance of the 2020 Notes (as defined below) and the Bridge Financing (as defined below) prior to the Merger and the Primary Financing completed on October 28, 2021, whereby the Company received funding of approximately $12 million ($10.1 million after offering costs) at the closing of the Merger.

On August 9, 2022, the Company completed an offering (the “Offering”) of ordinary shares represented by ADSs and pre-funded warrants to purchase ordinary shares represented by ADSs with each ADS and pre-funded warrant accompanied by an ordinary warrant, for aggregate gross proceeds of $16.8 million, resulting in net proceeds of approximately $15.0 million, after deducting the placement agent’s fees and estimated offering expenses payable by the Company (see Note 17). As a result of the completion of the Offering, the Company believes that it has sufficient resources to effect its business plan for at least one year from the issuance of these consolidated financial statements.

Additional financing will still be required to complete the research and development of the Company’s therapeutic targets and its other operating requirements until it achieves commercial profitability, if ever. Such financing may not be available at acceptable terms, if at all. If the Company is unable to obtain additional funding when it becomes necessary, the development of its product candidates will be impacted and the Company would likely be forced to delay, reduce, or terminate some or all of its development programs, all of which could have a material adverse effect on the Company’s business, results of operations and financial condition.

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

6 Months Ended

Jun. 30, 2022

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

NOTE 3 - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Presentation:

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) for interim financial information. Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete financial statements, reflecting the operations of Quoin Inc. since inception and include the accounts of Quoin Ltd. since the date of the Merger. In the opinion of management, such statements include all adjustments (consisting only of normal recurring items) which are considered necessary for a fair presentation of the unaudited condensed consolidated financial statements of the Company as of June 30, 2022 and for the three and six months then ended. The results of operations for the three and six months ended June 30, 2022 are not necessarily indicative of the operating results for the year or any other period. These unaudited condensed consolidated financial statements should be read in conjunction with the audited financial statements and related disclosures as of December 31, 2021 and for the year then ended which are included in the Company’s Annual Report on Form 20-F for the year ended December 31, 2021. The Company operates in one segment.

Use of estimates:

The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts in the financial statements and accompanying notes. Actual results could materially differ from those estimates. Management considers many factors in selecting appropriate financial accounting policies and controls, and in developing the estimates and assumptions that are used in the preparation of these financial statements. In addition, other factors may affect estimates, including: expected business and operational changes, sensitivity and volatility associated with the assumptions used in developing estimates, and whether historical trends are expected to be representative of future trends. The estimation process often may yield a range of potentially reasonable estimates of the ultimate future outcomes and management must select an amount that falls within that range of reasonable estimates.

Reclassification:

Certain 2021 amounts were reclassified to conform to the current year presentation. The amount reclassified included the short term portion from long term portion due to officers.

Other risks and uncertainties:

The Company is subject to risks common to development stage biopharmaceutical companies including, but not limited to, new technological innovations, dependence on key personnel, protection of proprietary technology, compliance with government regulations, product liability, pre-clinical and clinical trial outcome risks, regulatory approval risks, uncertainty of market acceptance and additional financing requirements.

The Company’s products require approval or clearance from the U.S. Food and Drug Administration (“FDA”) prior to commencing commercial sales in the United States. There can be no assurance that the Company’s products will receive all of the required approvals or clearances. Approvals or clearances are also required in foreign jurisdictions in which the Company may license or sell its products.

There can be no assurance that the Company’s products, if approved, will be accepted in the marketplace, nor can there be any assurance that any future products can be developed or manufactured at an acceptable cost and with appropriate performance characteristics, or that such products will be successfully marketed.

The Company is also dependent on several third party suppliers, in some cases single-source suppliers which include the supplier of the active pharmaceutical ingredient (API) as well as the contract manufacturer of the drug substance for the expected clinical development.

Coronavirus (“COVID-19”) created a global pandemic, which commenced in 2020. The Company’s operations, to date, have not been dramatically affected by COVID-19. However, the extent of any future impact on the Company’s operational and financial performance will depend on the possibility of a resurgence and resulting severity of COVID-19 with respect to the Company’s access to API and drug product for clinical testing , as well as our ability to safely and efficiently conduct planned clinical trials.

Cash:

The Company considers all highly liquid investments and short-term debt instruments with original maturities of three months or less to be cash equivalents. The Company, from time to time during the periods presented, has had bank account balances in excess of federally insured limits where substantially all cash is held in the United States. The Company has not experienced losses in such accounts. The Company believes that it is not subject to unusual credit risk beyond the normal credit risk associated with commercial banking relationships.

Long-lived assets:

Long-lived assets are comprised of acquired technology and licensed rights to use technology, which are considered platform technology with alternative future uses beyond the current products in development. Such intangible assets are being amortized on a straight-line basis over their expected useful life of 10 years.

The Company assesses the impairment for long-lived assets whenever events or circumstances indicate the carrying value may not be recoverable. Factors we consider that could trigger an impairment review include the following:

●

Significant changes in the manner of our use of the acquired assets or the strategy for our overall business,

●

Significant underperformance relative to expected historical or projected development milestones,

●

Significant negative regulatory or economic trends, and

●

Significant technological changes which could render the platform technology obsolete.

The Company recognizes impairment when the sum of the expected undiscounted future cash flows is less than the carrying amount of the asset. Impairment losses, if any, are measured as the excess of the carrying amount of the asset over its estimated fair value. During the three and six months ended June 30, 2022 and 2021, there were no impairment indicators which required an impairment loss measurement.

Research and development:

Research and development costs are expensed as incurred. Research and development expenses include personnel costs associated with research and development activities, including third-party contractors to perform research, conduct clinical trials and manufacture drug supplies and materials. The Company accrues for costs incurred by external service providers, including contract research organizations and clinical investigators, based on its estimates of service performed and costs incurred. These estimates include the level of services performed by third parties, patient enrollment in clinical trials when applicable, administrative costs incurred by third parties, and other indicators of the services completed. Based on the timing of amounts invoiced by service providers, the Company may also record payments made to those providers as prepaid expenses that will be recognized as expense in future periods as the related services are rendered.

Stock based compensation:

The Company recognizes compensation costs resulting from the issuance of stock-based awards to employees, non-employees and directors as an expense in the consolidated statements of operations over the requisite service period based on a measurement of fair value for each stock-based award. The fair value of each option grant to employees, non-employees and directors is estimated as of the date of grant using the Black-Scholes option-pricing model, net of actual forfeitures. The fair value is amortized as compensation cost on a straight-line basis over the requisite service period of the awards, which is generally the vesting period.

The Company’s expected stock volatility is based on the historical data regarding the volatility of a publicly traded set of peer companies, since it has limited history of trading as a public company. The Company utilizes the simplified method to estimate the expected term. The risk-free interest rate was determined by reference to the U.S. Treasury yield curve in effect at the time of grant of the award for time periods approximately equal to the expected term of the award. The expected dividend yield was assumed to be zero as the Company has not paid and dividends since its inception and does not anticipate paying dividends in the foreseeable future.

Income taxes:

The Company accounts for its income taxes using the asset and liability method. Accordingly, deferred tax assets and liabilities are recognized for future tax consequences attributable to differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases and tax credit carry-forwards. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date. Tax benefits are recognized when it is probable that the deduction will be sustained. A valuation allowance is established when it is more likely than not that all or a portion of a deferred tax asset will expire before the Company is able to realize the benefit, or that future deductibility is uncertain. As of June 30, 2022 and December 31, 2021, the Company maintained a full valuation allowance on its existing deferred tax assets.

The Company filed U.S. Federal, various state and international income tax returns. The Company also accounts for uncertain tax positions using the more-likely-than-not threshold for financial statement recognition and measurement of a tax position taken in the Company’s income tax returns. As of June 30, 2022 and December 31, 2021, the Company had no uncertain tax positions which affected its financial position and its results of operations or its cash flows and will continue to evaluate for uncertain tax positions in the future. If at any time the Company should record interest and penalties in connection with income taxes, the interest and the penalties will be expensed within the interest and general and administrative expenses, respectively.

Fair value of financial instruments:

The Company considers its cash, accounts payable, accrued expenses and the convertible and bridge notes payable to meet the definition of financial instruments. The convertible and bridge notes payable and related warrants are recorded at fair value, see Notes 4, 5 and 6. The carrying amounts of the remaining financial instruments approximated their fair values due to the short maturities.

The Company measures fair value as required by ASC Topic 820, Fair Value Measurements and Disclosures (“ASC Topic 820”). ASC Topic 820 defines fair value, establishes a framework and gives guidance regarding the methods used for measuring fair value, and expands disclosures about fair value measurements. ASC Topic 820 clarifies that fair value is an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants.

Earnings (loss) per share:

The Company reports loss per share in accordance with ASC 260-10, Earnings Per Share, which provides for calculation of “basic” and “diluted” earnings per share. Basic earnings per share includes no dilution and is computed by dividing net income or loss available to common shareholders by the weighted average common shares outstanding for the period. Diluted earnings per share reflect the potential dilution of securities that could share in the earnings of an entity. The calculation of diluted net earnings (loss) per share gives effect to ordinary shares equivalents; however, potential common shares are excluded if their effect is anti-dilutive.

For the three and six months ended June 30, 2022, the number of shares excluded from the diluted net earnings (loss) per share included outstanding options and warrants to purchase 309,115 ADSs and 1,052,904 ADSs, respectively. For the three and six months ended June 30, 2021, the 5,183 ADS’s issuable upon the conversion of both the Convertible Notes Payable (as defined below) and the 40,247 ADSs issuable upon conversion of the Bridge Notes (as defined below) as well as the warrants issued in connection with both of these convertible instruments are not included in the denominator since their inclusion would be anti-dilutive.

CONVERTIBLE NOTES PAYABLE

6 Months Ended

Jun. 30, 2022

CONVERTIBLE NOTES PAYABLE.

CONVERTIBLE NOTES PAYABLE

NOTE 4 – CONVERTIBLE NOTES PAYABLE

On October 2, 2020, Quoin Inc. commenced an offering of promissory notes (the “2020 Notes” or “Convertible Notes Payable”) and warrants. Based upon the terms agreed to in March 2021 in the Primary Financing (see Note 5), the 2020 Notes were mandatorily convertible into 5,183 ADSs in the Primary Financing, subject to adjustment.

The Company elected to account for the Convertible Notes Payable using the fair value model due to the short maturity and likely conversion at the date of the Merger. The fair value of the Convertible Notes Payable was estimated to be approximately $1.2 million at the date of issuance and there was no material change in the fair value from issuance until the conversion to equity on the closing of the Merger or the “Merger date”. At the closing of the Merger, 5,183 ADSs were issued upon the conversion of the principle of the Convertible Notes Payable.

The noteholders also received warrants exercisable at any time after the issuance date for a number of shares of Quoin Inc.’s common stock that equates to 100% of the “as if converted” shares as if the 2020 Notes principal and interest were convertible at the lowest price any securities are sold, convertible, or exercisable into in the Primary Financing or the next round of financing (whichever is lower). The terms of the warrants became measurable and were exercisable for 29,388 ADSs at an initial exercise price of $49.75 per ADS. The Company determined that these warrants met the criteria to be recorded as a liability instrument. Each holder agreed to exchange its warrant for warrants on substantially the same terms as the Investor Exchange Warrants (See Note 5) with the same number of shares issuable upon the exercise of an Exchange Warrant as upon the exercise of the original warrant and the same exercise price as under the original warrant and have a contractual term of 5 years.

Effective March 13, 2022, the Company exchanged the noteholders’ warrants for on the same terms as the Investor Exchange Warrants, exercisable for 29,388 ADSs, in the aggregate, at the exercise price of $49.75 per ADS. The Exchange Warrants have been determined to have equity classification. The change in the fair value of the warrants through the exchange date was included in other income (expense) in the accompanying statement of operations, and then reclassified from liability to additional paid in capital.

In December 2021, the Company concluded that the calculation of ADSs due to the 2020 Noteholders did not account for accrued interest due when the ADSs were issued. The Company’s estimated amount required to settle these obligations was determined to be approximately $744,000 at December 31, 2021, included in accrued interest in the accompanying consolidated balance sheet. Approximately $312,000 was paid to two of the five 2020 Noteholders during the three and six months ended June 30, 2022, and the remaining liability is $432,000 as of June 30, 2022. The Company expects to settle the remaining liability during 2022.

Interest expense, at the stated interest rate, recognized in the three and six months ended June 30, 2022 and 2021 was approximately $0 and $55,000 and $0 and $121,000, respectively.

BRIDGE FINANCING AND SECURITIES PURCHASE AGREEMENT (Primary Financing)

6 Months Ended

Jun. 30, 2022

BRIDGE FINANCING AND SECURITIES PURCHASE AGREEMENT (Primary Financing)

BRIDGE FINANCING AND SECURITIES PURCHASE AGREEMENT (Primary Financing)

NOTE 5 – BRIDGE FINANCING AND SECURITIES PURCHASE AGREEMENT (PRIMARY FINANCING)

Bridge Financing

In connection with the Merger Agreement and the Securities Purchase Agreement (described below), Quoin Inc. entered into a “Bridge Purchase Agreement” on March 24, 2021 with the Investor, pursuant to which the Investor agreed to purchase notes (the “Bridge Notes”) in the aggregate principal amount of up to $5,000,000 in exchange for an aggregate purchase price of up to $3,800,000 together with warrants. The Bridge Notes were purchased in three closings: (i) the first purchase of $2,000,000 on March 25, 2021 (proceeds of $1,500,000); (ii) the second purchase of $1,700,000 in April 2021 (proceeds of $1,250,000) ; and (iii) a third purchase of $1,300,000 in May 2021 (proceeds of $1,000,000).

The Bridge Notes were issued with a 25% original issue discount, at an interest rate of 15% per annum and had a maturity date of the earliest to occur of: (i) December 25, 2021, (ii) the date on which Quoin Inc.’s equity is registered under the Exchange Act or is exchanged for equity so registered or (iii) immediately prior to the closing of the Merger.

The Investor and Quoin Inc. agreed that if the Primary Financing is consummated, the Investor may, at its election, offset the purchase price otherwise payable by Investor to Quoin Inc. pursuant to the Securities Purchase Agreement related to the Primary Financing, by an amount equal to the outstanding amount under this Bridge Note, and, upon such set-off, the portion of this Bridge Note shall be deemed to have been paid in its entirety and all obligations thereunder shall be deemed to be fully satisfied without any further obligations on, or liability to, Quoin Inc.

The Company elected to account for the Bridge Notes using the fair value model due to the short maturity and likely conversion at the closing of the Merger. The cumulative fair value of the Bridge Notes was estimated to be approximately $5,000,000 at the date of issuances. The Bridge Notes were offset against the purchase price under the Securities Purchase Agreement related to the Primary Financing and converted into 100,618 ADSs (including shares held in escrow for the benefit of the Investor) upon the closing of the Primary Financing. The accrued interest, amounting to $393,611, was paid in cash at the Merger date. Interest expense, at the stated interest rate, recognized in the three and six months ended June 30, 2022 and 2021 was $0 and $142,100 and $0 and $147,000, respectively.

Bridge Warrants

Upon the funding of each Bridge Note tranches described above, the Investor received warrants (the “Bridge Warrants”) to purchase a number of shares of Quoin Inc.’s common stock equal to the aggregate principal amount of the Bridge Notes. The Bridge Warrants had a term of five years from the date all of the shares underlying the Bridge Warrants are freely tradable. Quoin Inc. issued a total of 99,074 Bridge Warrants in the year ended December 31, 2021.

Following the closing date of the Merger, on each of the tenth trading day, the forty-fifth day, the ninetieth day, and the one hundred thirty-fifth day thereafter (each, a “Reset Date”), if the initial exercise price of the Bridge Warrants is greater than the arithmetic average of 85% of the three lowest weighted average prices of the post-Merger ordinary shares of the combined company during the ten trading day period immediately preceding the applicable Reset Date (the “Reset Price”), the exercise price of the Bridge Warrants will be reset to the Reset Price. Furthermore, the number of shares underlying Bridge Warrants will be adjusted such that the aggregate number of shares of common stock issuable to the Investor reflects the Reset Price instead of the initial exercise price. Adjustments to the exercise price and number of warrant shares are available to the Investor until the second anniversary of the Registration Date, as defined in the Bridge Warrants. Upon the occurrence of a Fundamental transaction, as defined in the Bridge Warrants, the warrant holder has the right to elect a cash settlement for the value of the warrant based on the Black Scholes options pricing model.

The Company determined that the warrants met the criteria to be recorded as a liability instrument through the exchange date on the closing of the Primary Financing. The fair value of warrants was determined by a MonteCarlo simulation model to be approximately $1.6 million at the date of issuance of the 39,630 warrants in connection with the first closing and $2.2 million at the date of issuance of the 59,444 in connection with the second and third closing of the Bridge Notes.

Upon the closing of the Primary Financing, the Bridge Warrants were exchanged for warrants to purchase 99,074 ADSs at a fixed per share exercise price of $49.75 (“Investor Exchange Warrants”), as amended, which replaced the reset provisions and modified the fundamental transaction requirements of the Bridge Warrants. The Investor Exchange Warrants and ordinary shares underlying the Investor Exchange Warrants were registered with the SEC on the Registration Statement on Form F-4. On July 14, 2022 the Company and the Investor entered into an agreement amending the terms of the Exchange Warrants, see Note 17.

Primary Financing

On October 28, 2021, the Company completed the private placement transaction with the Investor for an aggregate purchase price of approximately $17.0 million (comprised of (x) the set off of approximately $5 million of Bridge Notes, and (y) approximately $12 million in cash from the Investor) (the “Primary Financing”), and the Investor paid the Company approximately $11,504,000, which was net of $393,611 in accrued interest on the Bridge Notes. The Company incurred an additional approximate $1.4 million in costs associated with the Primary Financing, which resulted in the net proceeds of approximately $10.1 million. The Company issued 342,100 ADSs to the Investor.

Quoin Ltd. also was required to issue to the Investor, effective as of March 13, 2022, the 136th day following the consummation of the Merger (i) Series A Warrant to purchase 342,100 ADSs (the “Series A Warrant”) (ii) Series B Warrant to purchase 342,100 ADSs (the “Series B Warrant”) and (iii) Series C Warrant to purchase 191,174 ADSs (“Series C Warrant” and, together with the Series A Warrant and Series B Warrant, the “Investor Warrants”). The exercise price for the Investor Warrants is $49.75 per ADS, with Series A Warrant having a five-year maturity, and Series B Warrant and Series C Warrant having a two-year maturity. The Company had the right to require the mandatory exercise of the Series C Warrant, subject to an effective registration statement being in place for the resale of the shares underlying such warrants and the satisfaction of equity market conditions, as defined in the Series C Warrant. On April 22, 2022, the registration statement was declared effective by the Securities and Exchange Commission, but not all of the market related conditions were met during the period up to July 14, 2022.

On July 14, 2022, the Company and the Investor entered into an agreement amending the terms of the Series A Warrant and cancelling the Series C Warrant, see Note 17.

FAIR VALUE OF FINANCIAL INSTRUMENTS

6 Months Ended

Jun. 30, 2022

FAIR VALUE OF FINANCIAL INSTRUMENTS

FAIR VALUE OF FINANCIAL INSTRUMENTS

NOTE 6 - FAIR VALUE OF FINANCIAL INSTRUMENTS

The Company applies fair value accounting for all assets and liabilities that are recognized or disclosed at fair value in the financial statements on a recurring basis. Fair value is defined as the price that would be received from selling an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. When determining the fair value measurements for assets and liabilities the Company considers the principal or most advantageous market in which it would transact and the market-based risk measurements or assumptions that market participants would use in pricing the asset or liability, such as risks inherent in valuation techniques, transfer restrictions and credit risk. For certain instruments, including cash and cash equivalents, accounts payable, and accrued expenses, it was estimated that the carrying amount approximated fair value because of the short maturities of these instruments.

Fair value is estimated using various valuation models, which utilize certain inputs and assumptions that market participants would use in pricing the asset or liability. The inputs and assumptions used in valuation models are classified in the fair value hierarchy as follows:

Level 1: Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities. The fair value hierarchy gives the highest priority to Level 1 inputs.

Level 2: Quoted market prices for similar instruments in an active market; quoted prices for identical or similar assets and liabilities in markets that are not active; and model-derived valuations inputs of which are observable and can be corroborated by market data.

Level 3: Unobservable inputs and assumptions that are supported by little or no market activity and that are significant to the fair value of the asset and liability. The fair value hierarchy gives the lowest priority to Level 3 inputs.

In determining the appropriate hierarchy levels, the Company analyzes the assets and liabilities that are subject to fair value disclosure. Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to their fair value measurement.

The significant inputs to the valuation model used in the determining the fair value of the 2020 Notes warrants (Note 4) were as follows:


	03/13/2022			12/31/2021
Stock price	$	18.50		$	22.75
Initial exercise price	$	49.75		$	49.75
Contractual Term		5.0			5.0
Volatility		91.5	%		89.2	%
Discount rate		1.94	%		1.26	%

The following table presents the Company’s assets and liabilities that are measured at fair value on a recurring basis by fair value hierarchy at December 31, 2021 (none at June 30, 2022):


December 31, 2021	Level 1	Level 2	Level 3		Total
2020 Notes warrants	—	—	$	373,599	$	373,599
Total Warrant Liability	—	—	$	373,599	$	373,599

The following shows the movement of the warrant liability balance during 2021 and the six months ended June 30, 2022.


	Bridge
	Financing		2020 Note
	Warrants		Warrants
Beginning Balance January 1, 2021	$	—	$	—
Warrant value at issuance (recorded as warrant liability expense)		3,783,079		894,113
Change in fair value of warrants		8,627,651		(520,514)
Reclassification of warrant liability to an equity instrument		(12,410,730)		—
Ending balance December 31, 2021	$	—	$	373,599

Change in fair value of warrants		—		(77,237)
Reclassification of warrant liability to an equity instrument		—		(296,362)
Ending balance June 30, 2022	$	—	$	—

The Investor Exchange Warrant issued to the Investor on the Merger date was determined to be an equity-classified instrument, and accordingly the warrant liability on such date of $12,410,730 was reclassified to additional paid in capital. The Exchange Warrants issued to the 2020 Noteholders effective as of March 13, 2022 were determined to be an equity-classified instrument, and accordingly the warrant liability on such date of $296,362 was reclassified to additional paid in capital on that date.

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

STOCK BASED COMPENSATION

6 Months Ended

Jun. 30, 2022

STOCK BASED COMPENSATION

STOCK BASED COMPENSATION

NOTE 7 – STOCK BASED COMPENSATION

In March 2022, the board of directors of the Company approved the Amended and Restated Equity Incentive Plan (the “Amended Plan”) which increased the number of ordinary shares reserved for issuance under such equity incentive plan to 15% of the Company’s outstanding ordinary shares on a fully-diluted basis, or 1,826,991,617 ordinary shares, represented by 365,398 ADSs as of June 30, 2022. Under the Amended Plan, the Company may grant options to its directors, officers, employees, consultants, advisers and service providers. The Amended Plan was approved by the shareholders at the Company’s Annual General Meeting of Shareholders held on April 12, 2022. The Amended Plan is an amendment and restatement of the 2014 Global Incentive Option Scheme (the “Scheme”). All options outstanding under the Scheme were fully vested and had a remaining life of less than one year at the Merger date.

On April 12, 2022, the Company has granted options to acquire 1,535,714,000 ordinary shares, represented by 307,142 ADSs, at $17.50 per share to founders, directors and employees and 58,255 shares remained available for issuance. Such options vest over a three or four year period.

The following table summarizes stock-based activities under the 2022 Quoin Stock Incentive Plan:


		Weighted		Weighted
		Average		Average
	ADS Underlying	Exercise		Contractual
	Options	Price		Terms
Outstanding at December 31, 2021	5,744	$	636.74	0.33
Granted	307,142	$	17.50	9.78
Exercised	0	$	0	0
Forfeited/Cancelled	(3,772)	$	0	0
Outstanding at June 30, 2022	309,114	$	19.56	9.72

Exercisable options at June 30, 2022	1,972	$	339.80	0.33

The following table summarizes the exercise price range as of June 30, 2022:


	Exercise Price	Outstanding Options	Exercisable
			Options
$	17.50	307,142	0
$	339.80	1,972	1,972
		309,114	1,972

The determination of fair value using the Black-Scholes model is affected by the Company’s share price as well as assumptions regarding a number of complex and subjective variables, including expected price volatility, risk-free interest rate and forfeitures.

Stock options granted during the three and six months ended June 30, 2022 were valued using the Black-Scholes option-pricing model with the following weighted average assumptions:


	June 30,
	2022
Expected volatility		106.0	%
Risk-free interest rate		2.7	%
Expected dividend yield		0.0	%
Expected life of options in years		6.9
Exercise Price	$	17.50
Fair value of common stock	$	15.38
Estimated fair value of option	$	12.92

The intrinsic value of outstanding options at June 30, 2022 was negligible.

Stock based compensation expense was approximately $229,000 ($30,000 included in research and development expense and $199,000 included in general and administrative expenses) in both the three and six months ended June 30, 2022. At June 30, 2022, the total unrecognized compensation expense related to non-vested options was approximately $3,739,529 and is expected to be recognized over the remaining weighted average service period of approximately 3.6 years.

PREPAID EXPENSES

6 Months Ended

Jun. 30, 2022

PREPAID EXPENSES

PREPAID EXPENSES

NOTE 8 – PREPAID EXPENSES

Prepaid expenses are as follows:


	June 30,		December 31,
	2022		2021
Prepaid R&D costs	$	552,159	$	329,033
Prepaid insurance		273,676		684,191
Prepaid other expenses		968		2,250
Total	$	826,803	$	1,015,474

ACCRUED EXPENSES

6 Months Ended

Jun. 30, 2022

ACCRUED EXPENSES

ACCRUED EXPENSES

NOTE 9 - ACCRUED EXPENSES

Accrued expenses are as follows:


	June 30,		December 31,
	2022		2021
Research contract expenses (note 13)	$	741,776	$	193,537
Payroll		573,511		557,937
Payroll taxes		153,552		199,582
Investor relations firm fees (note 13)		140,000		584,000
Professional fees		213,228		144,377
Other expenses		42,727		5,976
Total	$	1,864,794	$	1,685,409

IN-LICENSED TECHNOLOGY

6 Months Ended

Jun. 30, 2022

IN-LICENSED TECHNOLOGY

IN-LICENSED TECHNOLOGY

NOTE 10 – IN-LICENSED TECHNOLOGY

Polytherapeutics

On March 24, 2018, Quoin Inc. entered into a securities purchase agreement (the “Acquisition Agreement”), in which it agreed to acquire all of the equity interests in Polytherapeutics, Inc. (the “Seller” or “Polytherapeutics”) for $40,833 and future royalties provided Quoin Inc. commercializes products using the technology developed by the Seller. The terms of any royalty payments to the Seller are 4.0% of the net revenue of royalty products, as defined in the Acquisition Agreement, received by Quoin Inc. during the ten (10) year period commencing from the date of first sale of a royalty product. If a generic product is introduced by a third party to the market, during the royalty period, the royalty fees shall be reduced from 4% to 2%. If, during the royalty period, two or more generic products are introduced, the royalty fees shall be reduced from 2% to 0%.

The Seller had the option to repurchase the intellectual property for $100,000 if there were no products in clinical development using such technology. The repurchase option was not exercised and has lapsed.

Quoin Inc. also entered into a research and consulting agreement which committed Quoin Inc. to pay the Seller for additional research and development consulting services (See Notes 13 and 15).

Skinvisible:

On October 17, 2019, Quoin Inc. entered into an exclusive license agreement with Skinvisible Inc. (“Skinvisible”), pursuant to which Skinvisible granted a license to use certain patented technology for the development of products for commercial sale in the orphan rare skin disease field, and for the use of a proprietary polymer deliver system technology. This technology is currently being used in the development of QRX003. In exchange for the license, Quoin Inc. agreed to pay Skinvisible $1,000,000, as well as development and sales milestone payments and a single digit royalty on all net sales, as defined.

The development milestones originally required payments upon achieving development milestones for the first Rare Skin Disease drug product developed using the licensed technology and the first two Ketamine products, as defined. Payments were originally due upon successful completions of certain clinical milestones ($7.5 million) and obtaining US and EU regulatory approval ($15 million) as well as sales milestones for every licensed product commercialized by Quoin Inc.. On January 27, 2021, Quoin Inc. and Skinvisible entered into an amendment which modified the clinical milestone payment requirements such that $750,000 would be payable to Skinvisible upon achievement of specified clinical milestones, and $21.75 million upon regulatory approval in the U.S. and EU respectively.

The agreement has a termination clause that is triggered if no product has commenced clinical testing 12 months after the date of the agreement or the latest subsequent amendment. On April 19, 2021, Quoin Inc. and Skinvisible entered into another amendment which established the development deadline as December 31, 2022, which has been met.

The license fee was originally due in two equal installments of $500,000 payable no later than December 31, 2019 and June 30, 2020, which were not paid. The agreement was subsequently amended several times to extend the payment due dates. On June 21, 2021, the parties entered into the most recent amendment which modified the payment terms and required a payment of $107,500 on June 26, 2021, a payment of $250,000 within 10 days of the Primary Financing, and the remaining $250,000 upon the earlier of approval of an Investigatory New Drug application by the FDA or December 31, 2021. This amendment also eliminated the $750,000 clinical milestone payments described above, reduced the milestone payment upon regulatory approval of the product containing the Skinvisible technology in either the U.S. or E.U., whichever happens first to a total of $5,000,000.

At December 31, 2021, the license acquisition liability due of $250,000 was paid in May 2022.

INTANGIBLE ASSETS

6 Months Ended

Jun. 30, 2022

INTANGIBLE ASSETS

INTANGIBLE ASSETS

NOTE 11 - INTANGIBLE ASSETS

Intangible assets are as follows:


	June 30,		December 31,
	2022		2021
Acquired technology – Polytherapeutics	$	40,433	$	40,433
Technology license – Skinvisible		1,000,000		1,000,000
Total cost		1,040,433		1,040,433
Accumulated amortization		(283,850)		(231,829)
Net book value	$	756,583	$	808,604

The Company recorded amortization expense of approximately $52,000 ($26,000 per quarter) for both of the six months ended June 30, 2022 and 2021. The Company recorded amortization expense of approximately $26,000 for both of the three months ended June 30, 2022 and 2021. The annual amortization expense expected to be recorded for existing intangible assets for the years 2022 through 2026, and thereafter, is approximately $52,000, $104,000, $104,000, $104,000, $104,000, and $288,000, respectively.

RELATED PARTY TRANSACTIONS

6 Months Ended

Jun. 30, 2022

RELATED PARTY TRANSACTIONS

RELATED PARTY TRANSACTIONS

NOTE 12 - RELATED PARTY TRANSACTIONS

Employment Agreements and Due to Officers/Founders:

In March 2018, Quoin Inc. executed employment agreements with both of its officers who are also co-founders of Quoin Inc. The employment agreements for both officers/founders allow for a onetime expense that covers the salaries they would have otherwise been paid for efforts they undertook in the periods since inception. The salaries and benefits allowances provided for under the employment agreements began to accrue as the services were being provided by the officers/founders and are included in Due to Officers on the accompanying balance sheet.

Amounts due to the officers/founders consist of amounts specified in the employment agreements since inception through June 30, 2022 as well as reimbursable travel expenses and other amounts paid by them to third parties on behalf of Quoin Inc. The Company repaid $150,000 and $19,466 and $300,000 and $154,466 of such amounts due to officers/founders in the three and six months ended June 30, 2022 and 2021, respectively. Since the Merger closing, the Company has been repaying amounts due to officers/founders at a rate of $25,000 each per month.

Amounts due to officers at June 30, 2022 and December 31, 2021 consisted of the following:


	June 30,		December 31,
	2022		2021
Salaries and allowances	$	4,108,500		4,108,500
Invoices paid on behalf of the Company		315,232		615,232
Total		4,423,732		4,723,732
Less: Short-term portion		(600,000)		(600,000)
Long-term portion	$	3,823,733	$	4,123,732

Expenses

Research and development expense to a related party, incurred in the three and six months ended June 30, 2022 and 2021 was approximately $12,000 and $0 and $24,000 and $0, respectively.

See Note 13 for employment agreements.

RESEARCH, CONSULTING AGREEMENTS AND COMMITMENTS

6 Months Ended

Jun. 30, 2022

RESEARCH, CONSULTING AGREEMENTS AND COMMITMENTS

RESEARCH, CONSULTING AGREEMENTS AND COMMITMENTS

NOTE 13 – RESEARCH, CONSULTING AGREEMENTS AND COMMITMENTS

Research and consulting agreement:

Quoin Inc. entered into a research and consulting agreement (the “Research Agreement”) which commits it to pay the former owner of Polytherapeutics (the “Consultant” or “Seller”) to transfer the technical know-how of Polytherapeutics with respect to (i) good manufacturing practices (“GMP”), clinical and commercial manufacturing of the Company’s PolyDur polymer and (ii) formulation development of products utilizing the Company’s PharmaDur polymer (See Note 13). The agreement required monthly consulting payments of $20,833 beginning on July 31, 2018 and ending February 28, 2021 (the “Post-Closing Period”) for a total of $666,667 over the consulting period. Pursuant to an amendment, the Post-Closing Period was revised to terminate on December 31, 2020.

Through June 30, 2022 and the financial statement issuance date, the Company has not made any payments, the Consultant has not performed any services and the Company has not incurred or accrued for any expenses. See Note 15 for Consultant’s notification of breach of contract.

Other research consulting agreements:

Quoin Inc. entered into three consulting agreements with Axella Research LLC (“Axella”) to provide regulatory and pre- clinical/clinical services to the Company with respect to QRX003 and QRX004. The combined fees of the three agreements are approximately $270,000, payable as milestones are met. Quoin Inc. has also engaged Axella for additional services pursuant to separate work orders. Further, Quoin Inc. has two options to pay the milestones due 1) one half in equity of Quoin Inc. (at a pre-negotiated valuation) and one-half in cash or 2) entirely in cash, in which case a discount of approximately 20% would be applicable. The Company incurred no research and development expenses, in connection with these agreements, for both of the three and six months ended June 30, 2022 and 2021, as no services were provided.

In November 2020, Quoin Inc. entered into a Master Service Agreement for an initial term of three years with Therapeutics Inc. for managing preclinical and clinical development for new products in the field of dermatology. The agreement required the execution of individual work orders. Quoin Inc. may terminate any work order for any reason with 90 days written notice subject to costs incurred through termination and a defined termination fee, unless there is a material breach by Therapeutics Inc. The latest work order was entered into in June 2022 for a clinical study at an expected estimated cost of approximately $4.4 million and expected timing through the second quarter of 2024. For the three and six months ended June 30, 2022, and June 30, 2021, the Company incurred a research and development expense under this agreement of approximately $309,000 and $0, and $480,000 and $0, respectively.

In November 2021, the Company entered into a commitment for research related services associated with Netherton Syndrome of approximately $250,000 for an expected period of eighteen months. For the three and six months ended June 30, 2022, the Company incurred research and development costs related to this agreement of approximately $77,000 and $77,000, respectively.

In May 2022, the Company entered into a commitment for research related services associated with Scleroderma of approximately $610,000 for an expected period of eighteen months. As of June 30, 2022, the Company incurred prepaid research and development costs related to this agreement of approximately $220,000.

Consulting agreement:

Quoin Inc. entered into a consulting agreement with an Investor Relations (IR) firm, which provides for a monthly fee of $14,000. The agreement had an automatic annual renewal clause and has been in effect since November 2017. The Company owed the IR firm $584,000 as of December 31, 2021, which was included in accrued expenses in the accompanying balance sheet. In March 2022, the Company entered into a settlement agreement with the IR firm reducing the liability to $168,000, and recognized $416,000 as other income in the accompanying consolidated statement of operations. As of June 30, 2022, the balance of this liability is $140,000. For the three and six months ended June 30, 2021, the Company incurred expenses of $42,000 and $42,000, respectively. For the three and six months end June 30, 2022, the Company incurred expenses of $28,000 and $28,000, respectively.

Employment agreements:

The employment agreements entered into by Quoin Inc. with its two founders/officers provide for a combined base salary, including monthly allowances, of $996,000 per annum, a discretionary bonus and certain allowances and benefits. In the event of termination of the two founders/officers for reason other than cause, as defined in the employment agreements, the founders shall be entitled to two years of based salary and bonus.

In November 2021, the Company appointed and entered into an employment agreement with its Chief Financial Officer which provides for a base salary of $360,000 per annum, a discretionary bonus and certain allowances and benefits.

The Company held its Annual General Meeting on April 12, 2022, and which the Company’s shareholders approved, a modification of the annual compensation of the two founders to a combined base salary of $990,000 and to increase the annual discretionary bonus to not less than 45% of the annual base salary.

Performance milestones and Royalties:

See Note 10 for asset and in-licensed technology commitments.

Merger agreement commitment:

In consideration for the Share Transfer disclosed in Note 1, the pre-closing Cellect shareholders received a contingent value right (“CVR”) entitling the holders to earnouts during the Payment Period (as such term is defined in the Share Transfer Agreement), comprised mainly of payments upon sale, milestone payments, license fees and exit fees realized by EnCellX. In order to secure such right, shares constituting 40% of EnCellX share capital are held in escrow.

In connection with the Share Transfer, Cellect entered into a CVR Agreement with Mr. Eyal Leibovitz, in the capacity of Representative for the holders of CVRs, and Computershare Trust Company, N.A., a federally chartered trust company (the “Rights Agent”). Under the terms of the CVR Agreement, the holders of the Cellect ADSs immediately prior to the Merger had the right to receive, through their ownership of CVRs, their pro-rata share of the net Share Transfer consideration, making such holders of CVRs the indirect beneficiaries of the net payments under the Share Transfer. CVRs were recorded in a register administered by the Rights Agent but were not certificated. Since the Company will not receive any net proceeds from the CVR’s, there is no asset or liability recorded in the consolidated financial statements.

SHAREHOLDERS' EQUITY AND SHARE OWNERSHIP AND RIGHTS

6 Months Ended

Jun. 30, 2022

SHAREHOLDERS' EQUITY AND SHARE OWNERSHIP AND RIGHTS

SHAREHOLDERS' EQUITY AND SHARE OWNERSHIP AND RIGHTS

NOTE 14 – SHAREHOLDERS’ EQUITY AND SHARE OWNERSHIP AND RIGHTS

Quoin Inc.

On March 5, 2018, in connection with the incorporation as a Delaware corporation, Quoin Inc. issued 100 shares for a consideration of $100 split equally between the two founders and officers of Quoin Inc. In connection with the Merger transaction, the two founders exchanged their shares in Quoin Inc. for 240,292 ADSs in Quoin Ltd., which was subsequently reduced to 224,388 shares in May 2022 following the determination of the number of shares held in escrow allocated to certain former shareholders of Cellect. All share and per share amounts have been adjusted to reflect this recapitalization.

Quoin Ltd.

The Company held a Special General Meeting on February 28, 2022, at which the Company’s shareholders adopted the Amended and Restated Articles of Association of the Company. The Company held its Annual General Meeting on April 12, 2022, and which the Company’s shareholders approved an increase to the authorized share capital to 50,000,000,000 ordinary shares from 12,500,000,000, no par value. These ordinary shares are not redeemable and do not have any preemptive rights.

The Purchase Agreement (as defined below) provided that for a period of 180 days following the closing of the Offering, the Company will not effect or enter into an agreement to effect a “variable rate transaction” as defined in the Purchase Agreement. Further, the Company has agreed in the Purchase Agreement not to issue, enter into any agreement to issue or announce the issuance or proposed issuance of any ADSs or ordinary shares or their equivalents, subject to certain exceptions, for a period of 90 days after the closing of the Offering.

Holders of our ordinary shares have one vote for each ordinary share held on all matters submitted to a vote of shareholders at a shareholders meeting. The board of directors shall determine and provide a record date for each shareholders meeting and all shareholders at such record date may vote. Unless stipulated differently in the Companies Law or in the articles of association, all shareholders’ resolutions shall be approved by a simple majority vote.

Under Israeli law, the Company may declare and pay dividends only if, upon the determination of our board of directors, there is no reasonable concern that the distribution will prevent us from being able to meet the terms of our existing and foreseeable obligations as they become due. Under the Companies Law, the distribution amount is further limited to the greater of retained earnings or earnings generated over the two most recent years legally available for distribution according to our then last reviewed or audited financial statements, provided that the date of the financial statements is not more than six months prior to the date of distribution. In the event that the Company does not have retained earnings or earnings generated over the two most recent years legally available for distribution, the Company may seek the approval of the court in order to distribute a dividend. The court may approve our request if it determines that there is no reasonable concern that the payment of a dividend will prevent the Company from satisfying our existing and foreseeable obligations as they become due.

The Bank of New York Mellon, as depositary, has registered and delivered American Depositary Shares, also referred to as ADSs. Following an ADS ratio adjustment effective August 1, 2022 (See Note 17), each ADS represents five thousand (5,000) ordinary shares (or a right to receive five thousand (5,000) ordinary shares). Each ADS will also represent any other securities, cash or other property which may be held by the depositary. ADSs may be held either (a) directly (1) by having an American Depositary Receipt, also referred to as an ADR, which is a certificate evidencing a specific number of ADSs or (2) by having uncertificated ADSs, or (b) indirectly by holding a security entitlement in ADSs through a broker or other financial institution that is a direct or indirect participant in The Depository Trust Company, also called DTC.

In the three months ended June 30, 2022 the Investor exercised the Series B Warrant pursuant to the alternate cashless exercise rights of such warrant, which gives the Investor the sole option as elected by the Investor to receive 1.0 ADS for each warrant ADS underlying such warrant, resulting in the issuance of a total of 342,100 ADSs to the Investor, representing 1,710,500,800 ordinary shares.

Warrants

The following table summarizes warrant activities during the year ended December 31, 2021 and the six months ended June 30, 2022:


	ADSs	Weighted
	Underlying	Average
	Warrants	Exercise Price
Outstanding at December 31, 2020	—		—
Granted	128,463	$	49.75
Assumed as part of Merger	8,820		137.50
Outstanding at December 31, 2021	137,283	$	55.39
Granted	1,257,721		49.75
Exercised – cashless	(342,100)		—
Outstanding at June 30, 2022	1,052,904	$	50.49

The following vested warrants were outstanding at June 30, 2022, exercisable into ADSs (the Investor Exchange Warrants and Series A Warrant were amended and subsequently exercised in July and August 2022, and Series C Warrant and the remaining portion of Series A Warrant were cancelled, see Note 17) :


		Exercise		Year of
	ADSs (1)	Price		maturity
Warrants held by 2020 noteholders	29,388	$	49.75	2027
Exchange warrants held by Investor	99,074	$	49.75	2026
Warrants held by former Cellect warrant holders	8,820	$	137.50	2024
Series A warrant held by Investor (2)(4)	533,274	$	49.75	2027
Series B warrant held by Investor (2)(3)(4)	191,174	$	49.75	2024
Series C warrant held by Investor (2)	191,174	$	49.75	2024
Total	1,052,904

See Note 17 for subsequent amendment

Equity-classified warrants issued effective as of March 13, 2022 pursuant to the Primary Financing requirements.

The Series B Warrant provides for alternate cashless exercise pursuant to which the Investor has the sole option as elected by the Investor to receive 1.0 ADS for each warrant share being exercised in such cashless exercise

As of June 30, 2022, the Company expected to issue additional Series A and Series B Warrants, each to purchase 191,173 ADSs to the Investor upon exercise of the Series C Warrant, which are included in the totals in the table above. See Note 17 for subsequent amendment.

The intrinsic value of outstanding warrants at June 30, 2022 was negligible.

- Definition

The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.

+ References

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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Publisher FASB
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

CONTINGENCIES

6 Months Ended

Jun. 30, 2022

CONTINGENCIES

CONTINGENCIES

NOTE 15 – CONTINGENCIES

From time to time, the Company may become involved in various legal matters arising in the ordinary course of business. Management is unaware of any matters requiring accrual for related losses in the financial statements.

In February 2020, the seller of the equity interests in Polytherapeutics and party to the Research Agreement communicated with Quoin Inc. threatening litigation for non-payment and related breach of contract and immediate payment of all monthly payments in the amount of $666,667. See Notes 9 and 13. The Consultant has not provided any services and has not complied with other technical requirements under the Research Agreement, and therefore is considered to be in breach of contract. The Company and the Consultant have had communications with respect to the duration, commencement date and payment of the consulting services, but a revised agreement has not been reached. No lawsuits have been filed as of the financial statement issuance date. Should a formal claim or lawsuit be filed, the Company believes it has meritorious defenses.

Nasdaq Listing

On April 22, 2022, we received a letter from the Listing Qualifications staff (the “Staff”) of The Nasdaq Stock Market, LLC (“Nasdaq”) notifying us that we are no longer in compliance with the minimum stockholders’ equity requirement for continued listing on The Nasdaq Capital Market. Nasdaq Listing Rule 5550(b)(1) requires listed companies to maintain stockholders’ equity of at least $2.5 million. In addition, as of April 21, 2022, we did not meet the alternative continued listing requirements based on market value of listed securities or net income from continuing operations. Based on our Form 6-K, dated August 10, 2022, the Staff has determined that we comply with the minimum stockholder’s equity requirement. However, if we fail to evidence compliance upon filing our Form 6-K with

financial statements for the quarter ending September 30, 2022, we may be subject to delisting. At that time, the Staff will provide written notification to us, and we may then appeal the Staff’s determination to a Hearings Panel.

On June 10, 2022, we received a letter from the Nasdaq Listing Qualifications staff notifying us that the closing bid price per ADS was below the required minimum of $1.00 for a period of 30 consecutive business days and that we did not meet the minimum bid price requirements set forth in Nasdaq Listing Rule 5550(a)(2). Since then, the Staff has determined that for the 10 consecutive business days, from August 1 to August 12, 2022, the closing bid price of our ADSs has been at $1.00 per ADS or greater, and we have regained compliance with the minimum bid price requirement.

As of the date of these consolidated financial statements, we believe that our stockholders’ equity exceeds $2.5 million due to the completion of the Offering. However, there can be no assurance that we will be able to maintain compliance with Nasdaq’s minimum stockholders’ equity requirement or minimum bid-price requirement for continued listing. If our ADSs are delisted from Nasdaq, it will have material negative impacts on the actual and potential liquidity of our securities, as well as material negative impacts on our ability to raise future capital.

LICENSE AGREEMENTS

6 Months Ended

Jun. 30, 2022

LICENSE AGREEMENTS

LICENSE AGREEMENTS

NOTE 16 – LICENSE AGREEMENTS

In November and December 2021, the Company entered into three license and supply agreements, whereby the Company is entitled to a royalty or other proceeds from the specified product revenues in select non-US markets from the licensee, if and when the underlying products are approved and commercialized. During six months ended June 30, 2022, the Company entered into five license and supply agreements, whereby the Company will receive a royalty or other proceeds from the specified product revenues in select non-US markets from the licensor, if and when the underlying products are approved and commercialized. No royalty revenues have been received through June 30, 2022 under any of these agreements.

SUBSEQUENT EVENTS

6 Months Ended

Jun. 30, 2022

SUBSEQUENT EVENTS

SUBSEQUENT EVENTS

NOTE 17 - SUBSEQUENT EVENTS

Public Offering

On August 9, 2022 the Company completed an offering (the “Offering”) of 11,050,000,000 ordinary shares represented by 2,210,000 ADSs at a purchase price of $5.00 per ADS and pre-funded warrants (the “Pre-Funded Warrants”) to purchase 5,750,000,000 ordinary shares represented by 1,150,000 ADSs at a per pre-funded warrant price of $4.9999, with each ADS and Pre-Funded Warrant accompanied by an ordinary warrant (the “Common Warrant”), for aggregate gross proceeds of $16.8 million, resulting in net proceeds of approximately $15.0 million, after deducting the placement agent’s fees and estimated offering expenses payable by the Company, and excluding the proceeds, if any, from the subsequent exercise of the Common Warrants. Each Common Warrant has an exercise price of $5.00 per ADS and expires on the fifth anniversary of the Closing Date. On the Closing Date, the holder of Pre-Funded Warrants sold in the Offering exercised its Pre-Funded Warrants in full.

In connection with the Offering, the Company entered into a Securities Purchase Agreement (the “Purchase Agreement”) with certain institutional investors. The Purchase Agreement provided that for a period of 180 days following the closing of the Offering, the Company will not effect or enter into an agreement to effect a “variable rate transaction” as defined in the Purchase Agreement. Further, the Company has agreed in the Purchase Agreement not to issue, enter into any agreement to issue or announce the issuance or proposed issuance of any ADSs or ordinary shares or their equivalents, subject to certain exceptions, for a period of 90 days after the closing of the Offering. The Purchase Agreement also contained representations, warranties, indemnification and other provisions customary for transactions of this nature.

ADS Ratio Change

On July 12, 2022, our Board of Directors approved the change in the ratio of ADS evidencing ordinary shares from 1 ADS representing four hundred (400) ordinary shares to 1 ADS representing five thousand (5,000) ordinary shares, which will result in a one for 12.5 reverse split of the issued and outstanding ADSs (the “Ratio Change”). The Ratio Change was effective August 1, 2022. All ADS and related option and warrant information presented in these financial statements and accompanying footnotes has been retroactively adjusted to reflect the reduced number of ADSs resulting from the Ratio Change.

Agreements with Altium Growth Fund, LP and Altium Warrant Exercises

On July 14, 2022, the Company, Quoin Inc. and Altium entered into an agreement (the “Altium Agreement”), pursuant to which the parties agreed to, among other things, (i) amend certain terms of the Series A Warrant and Investor Exchange Warrants previously issued to Altium to, among other things, reduce the exercise price to $0.00 per ADS with respect to a total of 399,999 ADSs, (ii) cancel the Series C Warrant and the remaining portion of the Series A Warrant previously issued to Altium, and (iii) terminate the Purchase Agreements, pursuant to which the warrants were previously issued to Altium. From July 15, 2022 to August 2, 2022, Altium exercised Series A Warrant to purchase 300,925 ADSs and Investor Exchange Warrants to purchase 99,074 ADSs at $0.00 per ADS exercise price, and we issued a total of 399,999 ADSs to Altium. As a result of the exercises and cancellation, there are no warrants outstanding to Altium at the financial statement issuance date.

The exercise price of the warrants held by the 2020 noteholders was also reduced to $0.00 as of July 14, 2022 as a result of the Altium Agreement. From July 15, 2022 to August 10, 2022, the 2020 Noteholders exercised warrants to purchase 26,172 ADSs at $0.00 per ADS exercise price, and we issued a total of 26,172 ADSs to such noteholders. As a result of the exercises, there were 3,216 warrants outstanding at the financial statement issuance date.

Shares and Warrants Outstanding

As a result of the above described events, there are 23,996,009,799 ordinary shares outstanding as of the financial statement filing date, 99.99% of which are represented by 4,799,129 ADSs.

The warrants outstanding as of the financial statement filing date are set out below, exercisable into ADSs:


		Exercise		Year of
	ADSs	Price		maturity
Warrants held by 2020 noteholders	3,216	$	0	2027
Warrants held by former Cellect warrant holders	8,820	$	137.5	2024
Common Warrants issued in the Offering	3,360,000	$	5.00	2027
Total	3,372,036

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)

6 Months Ended

Jun. 30, 2022

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Basis of Presentation:

Use of estimates:

Reclassification:

Certain 2021 amounts were reclassified to conform to the current year presentation. The amount reclassified included the short term portion from long term portion due to officers.

Other risks and uncertainties:

Cash:

Long-lived assets:

●

Significant changes in the manner of our use of the acquired assets or the strategy for our overall business,

●

Significant underperformance relative to expected historical or projected development milestones,

●

Significant negative regulatory or economic trends, and

●

Significant technological changes which could render the platform technology obsolete.

Research and development:

Stock based compensation:

Income taxes:

Fair value of financial instruments:

Earnings (loss) per share:

FAIR VALUE OF FINANCIAL INSTRUMENTS (Tables)

6 Months Ended

Jun. 30, 2022

Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]

Schedule of significant estimates used in the determining the fair value of warrants


	03/13/2022			12/31/2021
Stock price	$	18.50		$	22.75
Initial exercise price	$	49.75		$	49.75
Contractual Term		5.0			5.0
Volatility		91.5	%		89.2	%
Discount rate		1.94	%		1.26	%

Schedule of assets and liabilities measured at fair value on a recurring basis


December 31, 2021	Level 1	Level 2	Level 3		Total
2020 Notes warrants	—	—	$	373,599	$	373,599
Total Warrant Liability	—	—	$	373,599	$	373,599

Schedule of movement in warrant liability balance


	Bridge
	Financing		2020 Note
	Warrants		Warrants
Beginning Balance January 1, 2021	$	—	$	—
Warrant value at issuance (recorded as warrant liability expense)		3,783,079		894,113
Change in fair value of warrants		8,627,651		(520,514)
Reclassification of warrant liability to an equity instrument		(12,410,730)		—
Ending balance December 31, 2021	$	—	$	373,599

Change in fair value of warrants		—		(77,237)
Reclassification of warrant liability to an equity instrument		—		(296,362)
Ending balance June 30, 2022	$	—	$	—

STOCK BASED COMPENSATION (Tables)

6 Months Ended

Jun. 30, 2022

STOCK BASED COMPENSATION

Summary of stock-based activities


		Weighted		Weighted
		Average		Average
	ADS Underlying	Exercise		Contractual
	Options	Price		Terms
Outstanding at December 31, 2021	5,744	$	636.74	0.33
Granted	307,142	$	17.50	9.78
Exercised	0	$	0	0
Forfeited/Cancelled	(3,772)	$	0	0
Outstanding at June 30, 2022	309,114	$	19.56	9.72

Exercisable options at June 30, 2022	1,972	$	339.80	0.33

Summary of exercise price range


	Exercise Price	Outstanding Options	Exercisable
			Options
$	17.50	307,142	0
$	339.80	1,972	1,972
		309,114	1,972

Summary of weighted average assumptions of stock options granted valued using the Black-Scholes option-pricing model


	June 30,
	2022
Expected volatility		106.0	%
Risk-free interest rate		2.7	%
Expected dividend yield		0.0	%
Expected life of options in years		6.9
Exercise Price	$	17.50
Fair value of common stock	$	15.38
Estimated fair value of option	$	12.92

PREPAID EXPENSES (Tables)

6 Months Ended

Jun. 30, 2022

PREPAID EXPENSES

Schedule of Prepaid expenses


	June 30,		December 31,
	2022		2021
Prepaid R&D costs	$	552,159	$	329,033
Prepaid insurance		273,676		684,191
Prepaid other expenses		968		2,250
Total	$	826,803	$	1,015,474

ACCRUED EXPENSES (Tables)

6 Months Ended

Jun. 30, 2022

ACCRUED EXPENSES

Schedule of accrued expenses


	June 30,		December 31,
	2022		2021
Research contract expenses (note 13)	$	741,776	$	193,537
Payroll		573,511		557,937
Payroll taxes		153,552		199,582
Investor relations firm fees (note 13)		140,000		584,000
Professional fees		213,228		144,377
Other expenses		42,727		5,976
Total	$	1,864,794	$	1,685,409

INTANGIBLE ASSETS (Tables)

6 Months Ended

Jun. 30, 2022

INTANGIBLE ASSETS

Schedule of intangible assets


	June 30,		December 31,
	2022		2021
Acquired technology – Polytherapeutics	$	40,433	$	40,433
Technology license – Skinvisible		1,000,000		1,000,000
Total cost		1,040,433		1,040,433
Accumulated amortization		(283,850)		(231,829)
Net book value	$	756,583	$	808,604

RELATED PARTY TRANSACTIONS (Tables)

6 Months Ended

Jun. 30, 2022

RELATED PARTY TRANSACTIONS

Amounts due to offices


	June 30,		December 31,
	2022		2021
Salaries and allowances	$	4,108,500		4,108,500
Invoices paid on behalf of the Company		315,232		615,232
Total		4,423,732		4,723,732
Less: Short-term portion		(600,000)		(600,000)
Long-term portion	$	3,823,733	$	4,123,732

SHAREHOLDERS' EQUITY AND SHARE OWNERSHIP AND RIGHTS (Tables)

6 Months Ended

Jun. 30, 2022

SHAREHOLDERS' EQUITY AND SHARE OWNERSHIP AND RIGHTS

Schedule of stock options and warrants outstanding


		Exercise		Year of
	ADSs (1)	Price		maturity
Warrants held by 2020 noteholders	29,388	$	49.75	2027
Exchange warrants held by Investor	99,074	$	49.75	2026
Warrants held by former Cellect warrant holders	8,820	$	137.50	2024
Series A warrant held by Investor (2)(4)	533,274	$	49.75	2027
Series B warrant held by Investor (2)(3)(4)	191,174	$	49.75	2024
Series C warrant held by Investor (2)	191,174	$	49.75	2024
Total	1,052,904

See Note 17 for subsequent amendment

Equity-classified warrants issued effective as of March 13, 2022 pursuant to the Primary Financing requirements.

The warrants outstanding as of the financial statement filing date are set out below, exercisable into ADSs:


		Exercise		Year of
	ADSs	Price		maturity
Warrants held by 2020 noteholders	3,216	$	0	2027
Warrants held by former Cellect warrant holders	8,820	$	137.5	2024
Common Warrants issued in the Offering	3,360,000	$	5.00	2027
Total	3,372,036

Summary of warrant activities


	ADSs	Weighted
	Underlying	Average
	Warrants	Exercise Price
Outstanding at December 31, 2020	—		—
Granted	128,463	$	49.75
Assumed as part of Merger	8,820		137.50
Outstanding at December 31, 2021	137,283	$	55.39
Granted	1,257,721		49.75
Exercised – cashless	(342,100)		—
Outstanding at June 30, 2022	1,052,904	$	50.49

SUBSEQUENT EVENTS (Tables)

6 Months Ended

Jun. 30, 2022

SUBSEQUENT EVENTS

Schedule of warrants outstanding


		Exercise		Year of
	ADSs (1)	Price		maturity
Warrants held by 2020 noteholders	29,388	$	49.75	2027
Exchange warrants held by Investor	99,074	$	49.75	2026
Warrants held by former Cellect warrant holders	8,820	$	137.50	2024
Series A warrant held by Investor (2)(4)	533,274	$	49.75	2027
Series B warrant held by Investor (2)(3)(4)	191,174	$	49.75	2024
Series C warrant held by Investor (2)	191,174	$	49.75	2024
Total	1,052,904

See Note 17 for subsequent amendment

Equity-classified warrants issued effective as of March 13, 2022 pursuant to the Primary Financing requirements.

The warrants outstanding as of the financial statement filing date are set out below, exercisable into ADSs:


		Exercise		Year of
	ADSs	Price		maturity
Warrants held by 2020 noteholders	3,216	$	0	2027
Warrants held by former Cellect warrant holders	8,820	$	137.5	2024
Common Warrants issued in the Offering	3,360,000	$	5.00	2027
Total	3,372,036

ORGANIZATION AND BUSINESS (Details) - USD ($)	Aug. 01, 2022	Oct. 28, 2021	Jun. 30, 2022	Mar. 31, 2022	Dec. 31, 2021	Jun. 30, 2021	Mar. 31, 2021	Mar. 24, 2021	Dec. 31, 2020
Sale of stock
Ordinary shares, shares issued			5,065,154,799		3,354,650,799
Ordinary shares, shares outstanding			5,065,154,799		3,354,650,799
Shares owned (as a percent)	12.50%	12.00%
Bridge Notes
Sale of stock
Aggregate purchase price		$ 12,000,000
Debt instrument, face amount								$ 5,000,000
Cellect shareholders immediately prior to the merger
Sale of stock
Shares owned (as a percent)		88.00%
Private Placement
Sale of stock
Aggregate purchase price		$ 17,000,000.0
Debt instrument, face amount		12,000,000
Private Placement \| Bridge Notes
Sale of stock
Aggregate purchase price		$ 5,000,000
Minimum
Sale of stock
Number of shares represented for one ADS	(400)
Maximum [Member]
Sale of stock
Number of shares represented for one ADS	(5,000)
ADS
Sale of stock
Number of ADS shares available		8,386,627
Number of shares represented for one ADS		5,000
Ordinary shares, shares issued			1,013,031		670,930
Ordinary shares, shares outstanding			1,013,031	670,931	670,930	240,292	240,292		240,292

LIQUIDITY RISKS AND UNCERTAINTIES (Details) - USD ($) $ in Millions	Aug. 09, 2022	Jun. 30, 2022	Oct. 28, 2021
Substantial Doubt About Going Concern Line Items
Accumulated deficit		$ 32.4
ADS
Substantial Doubt About Going Concern Line Items
Proceeds from exercised warrants	$ 16.8
Net Proceeds From Issuance Of Warrants After Deducting Agent's Fees	$ 15.0
2020 Notes
Substantial Doubt About Going Concern Line Items
Proceeds received			$ 12.0
Deferred Offering Costs			$ 10.1

- Definition

Accumulated change in equity from transactions and other events and circumstances from non-owner sources, net of tax effect, at period end. Excludes Net Income (Loss), and accumulated changes in equity from transactions resulting from investments by owners and distributions to owners. Includes foreign currency translation items, certain pension adjustments, unrealized gains and losses on certain investments in debt and equity securities, other than temporary impairment (OTTI) losses related to factors other than credit losses on available-for-sale and held-to-maturity debt securities that an entity does not intend to sell and it is not more likely than not that the entity will be required to sell before recovery of the amortized cost basis, as well as changes in the fair value of derivatives related to the effective portion of a designated cash flow hedge.

+ References + Details

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Basis of Presentation (Details)	6 Months Ended
	Jun. 30, 2022 segment
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Number of operating segment	1

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Long-lived assets & Income taxes (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Intangible assets, useful life			10 years
Impairment loss measurement	$ 0	$ 0	$ 0	$ 0
Uncertain tax positions	$ 0		$ 0		$ 0

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - Earnings per share (Details) - shares	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Outstanding warrants
Antidilutive securities excluded from diluted computation
Antidilutive securities	1,052,904		1,052,904
Outstanding warrants \| ADS
Antidilutive securities excluded from diluted computation
Antidilutive securities	309,115		309,115
Warrants
Antidilutive securities excluded from diluted computation
Antidilutive securities		40,247		40,247
Warrants \| ADS
Antidilutive securities excluded from diluted computation
Antidilutive securities		5,183		5,183

CONVERTIBLE NOTES PAYABLE - 2020 Notes (Details) - USD ($) $ / shares in Units, $ in Millions	1 Months Ended	6 Months Ended
	Mar. 31, 2021	Jun. 30, 2022	Mar. 13, 2022	Dec. 31, 2020
Convertible Notes Warrants, Common Stock
Debt Instrument [Line Items]
Fair value of convertible notes				$ 1.2
Shares warrants may purchase			29,388
Warrants, exercise price of warrants (in dollars per share)			$ 49.75
Contractual term		5 years
2020 Notes
Debt Instrument [Line Items]
Shares warrants may purchase		29,388
Warrants, exercise price of warrants (in dollars per share)		$ 49.75
2020 Notes \| Convertible Notes Warrants, Common Stock
Debt Instrument [Line Items]
Shares issued upon conversion	5,183
Equivalent percentage of warrants received		100.00%

CONVERTIBLE NOTES PAYABLE - Interest Expense (Details)	3 Months Ended		6 Months Ended
CONVERTIBLE NOTES PAYABLE - Interest Expense (Details)	Jun. 30, 2022 USD ($) item	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($) item	Jun. 30, 2021 USD ($)	Dec. 31, 2021 USD ($)
Debt Instrument [Line Items]
Accrued interest	$ 432,170		$ 432,170		$ 743,840
Remaining liability	432,170		432,170		743,840
Interest expense	0	$ 0	142,100	$ 147,000
2020 Notes
Debt Instrument [Line Items]
Accrued interest	432,000		432,000		744,000
Repayment amount	$ 312,000		$ 312,000
Number of notes holders \| item	2		2
Number of notes holders who received consideration \| item	5		5
Remaining liability	$ 432,000		$ 432,000		$ 744,000
Interest expense	$ 0	$ 0	$ 55,000	$ 121,000

BRIDGE FINANCING AND SECURITIES PURCHASE AGREEMENT (Primary Financing) - Bridge Financing (Details) - USD ($)		3 Months Ended		6 Months Ended
	Mar. 24, 2021	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Debt Instrument [Line Items]
Fair value adjustment to convertible notes payable			$ (750,000)		$ (1,250,000)
Interest expense		$ 0	0	$ 142,100	147,000
2020 Notes
Debt Instrument [Line Items]
Interest expense		$ 0	$ 0	$ 55,000	$ 121,000
Bridge Notes
Debt Instrument [Line Items]
Debt instrument, face amount	$ 5,000,000
Debt instrument, aggregate purchase price	$ 3,800,000
Debt instrument, par, discount percentage (as a percent)	25.00%
Debt instrument, interest rate, stated percentage (as a percent)	15.00%
Long-term debt, fair value	$ 5,000,000
Debt conversion, converted instrument, shares issued	100,618
Interest paid	$ 393,611
Bridge Notes, First Closing, March 25, 2021
Debt Instrument [Line Items]
Debt instrument, aggregate purchase price	2,000,000
Proceeds from convertible debt	1,500,000
Bridge Notes, Second Purchase, April 2021
Debt Instrument [Line Items]
Debt instrument, aggregate purchase price	1,700,000
Proceeds from convertible debt	1,250,000
Bridge Notes, Third Purchase, May 2021
Debt Instrument [Line Items]
Debt instrument, aggregate purchase price	1,300,000
Proceeds from convertible debt	$ 1,000,000

BRIDGE FINANCING AND SECURITIES PURCHASE AGREEMENT (Primary Financing) - Bridge Warrants - General Information (Details) - USD ($) $ in Millions	Jun. 30, 2022	Dec. 31, 2021	Jun. 30, 2021
Bridge Warrants, Common Stock
Class of Warrant or Right [Line Items]
Warrants, term			5 years
Warrants, number of securities called by warrants (in shares)		99,074
Warrants, exercise price of the three lowest weighted-average prices of post-merger ordinary shares, threshold, percentage (as a percent)	85.00%
Bridge Warrants, Common Stock, First Closing
Class of Warrant or Right [Line Items]
Warrants, number of securities called by warrants (in shares)	39,630
Warrant liability	$ 1.6
Bridge Warrants, Common Stock, Second and Third Closings
Class of Warrant or Right [Line Items]
Warrants, number of securities called by warrants (in shares)	59,444
Warrant liability	$ 2.2

BRIDGE FINANCING AND SECURITIES PURCHASE AGREEMENT (Primary Financing) - Exchange Warrants (Details) - Exchange Warrants, American Depositary Shares	Jun. 30, 2022 $ / shares shares
Class of Warrant or Right [Line Items]
Warrants, number of securities called by warrants (in shares) \| shares	99,074
Warrants, exercise price of warrants (in dollars per share) \| $ / shares	$ 49.75

BRIDGE FINANCING AND SECURITIES PURCHASE AGREEMENT (Primary Financing) - Investor Warrants (Details) - USD ($)	Mar. 13, 2022	Oct. 28, 2021	Mar. 24, 2021
Class of Warrant or Right [Line Items]
Proceeds from sale of common stock, net		$ 11,504,000
Proceeds from sale of common stock, net of accrued interest and legal fess		1,400,000
Net proceeds		10,100,000
Bridge Notes
Class of Warrant or Right [Line Items]
Aggregate purchase price		12,000,000
Debt Instrument, Face Amount			$ 5,000,000
Private Placement
Class of Warrant or Right [Line Items]
Aggregate purchase price		17,000,000.0
Debt Instrument, Face Amount		12,000,000
Proceeds from sale of common stock, net of accrued interest and legal fess		$ 393,611
Sale of common stock, including conversion of Bridge Notes		342,100
Private Placement \| Bridge Notes
Class of Warrant or Right [Line Items]
Aggregate purchase price		$ 5,000,000
Series A Warrants, American Depositary Shares
Class of Warrant or Right [Line Items]
Warrants, number of securities called by warrants (in shares)	342,100
Series B Warrants, American Depositary Shares
Class of Warrant or Right [Line Items]
Warrants, number of securities called by warrants (in shares)	342,100
Series C Warrants, American Depositary Shares [Member]
Class of Warrant or Right [Line Items]
Warrants, number of securities called by warrants (in shares)	191,174
Series A Warrants, American Depositary Shares, Series C Warrants Exercised in Full
Class of Warrant or Right [Line Items]
Warrants, exercise price of warrants (in dollars per share)	$ 49.75
Investor warrants maturity term	5 years
Series B Warrants, American Depositary Shares, Series C Warrants Exercised in Full
Class of Warrant or Right [Line Items]
Investor warrants maturity term	2 years

FAIR VALUE OF FINANCIAL INSTRUMENTS (Details)	Mar. 13, 2022 Y $ / shares	Dec. 31, 2021 Y $ / shares
Stock price
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Measurement input	18.50	22.75
Initial exercise price
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Measurement input	49.75	49.75
Contractual Term
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Measurement input \| Y	5.0	5.0
Volatility
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Measurement input	91.5	89.2
Discount rate
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Measurement input	1.94	1.26

FAIR VALUE OF FINANCIAL INSTRUMENTS - Fair value on a recurring basis (Details)	Dec. 31, 2021 USD ($)
Assets and liabilities measured on a recurring basis
Warrant liability	$ 373,599
Recurring
Assets and liabilities measured on a recurring basis
Warrant liability	373,599
Recurring \| 2020 Notes Warrants
Assets and liabilities measured on a recurring basis
Warrant liability	373,599
Recurring \| Level 3
Assets and liabilities measured on a recurring basis
Warrant liability	373,599
Recurring \| Level 3 \| 2020 Notes Warrants
Assets and liabilities measured on a recurring basis
Warrant liability	$ 373,599

FAIR VALUE OF FINANCIAL INSTRUMENTS - Change in fair value (Details) - USD ($)	3 Months Ended	6 Months Ended	12 Months Ended
	Mar. 31, 2022	Jun. 30, 2022	Dec. 31, 2021
Change in fair value
Warrant liability			$ 373,599
Movement of warrant liability
Warrant liability reclassified to additional paid in capital	$ 296,362
Bridge Financing Warrants
Movement of warrant liability
Warrant value at issuance (recorded as warrant liability expense)			3,783,079
Change in fair value of warrants			8,627,651
Reclassification of warrant liability to an equity instrument			(12,410,730)
2020 Notes Warrants
Movement of warrant liability
Beginning Balance	$ 373,599	$ 373,599
Warrant value at issuance (recorded as warrant liability expense)			894,113
Change in fair value of warrants		(77,237)	(520,514)
Reclassification of warrant liability to an equity instrument		(296,362)
Ending Balance			$ 373,599
Warrant liability reclassified to additional paid in capital		$ 296,362

STOCK BASED COMPENSATION (Details) - $ / shares		1 Months Ended	6 Months Ended	12 Months Ended
STOCK BASED COMPENSATION (Details) - $ / shares	Apr. 12, 2022	Mar. 31, 2022	Jun. 30, 2022	Dec. 31, 2021
STOCK BASED COMPENSATION
Exercised (in dollars per share)			$ 49.75	$ 49.75
ADS
STOCK BASED COMPENSATION
Granted			1,257,721	128,463
Amended and Restated Equity Incentive Plan
STOCK BASED COMPENSATION
Percentage of ordinary shares reserved for issuance		15.00%
Number of ordinary shares reserved for future issuance			1,826,991,617
Number of shares acquired on exercise of options granted	1,535,714,000
Number of shares available for issuance	58,255
Amended and Restated Equity Incentive Plan \| Minimum
STOCK BASED COMPENSATION
Vesting period	3 years
Amended and Restated Equity Incentive Plan \| ADS
STOCK BASED COMPENSATION
Number of ordinary shares reserved for future issuance			365,398
Granted	307,142
Exercised (in dollars per share)	$ 17.50
Vesting period	4 years
2014 Global Incentive Option Scheme \| Maximum
STOCK BASED COMPENSATION
Remaining life of options			1 year

STOCK BASED COMPENSATION - Option activity (Details) - $ / shares	6 Months Ended	12 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
Weighted Average Exercise Price
Balance at the beginning (in dollars per share)	$ 55.39
Granted (in dollars per share)	49.75	$ 49.75
Exercised (in dollars per share)	49.75	49.75
Balance at the end (in dollars per share)	$ 50.49	$ 55.39
2022 Quoin Stock Incentive Plan
Number of Options
Outstanding at beginning	5,744
Options granted	307,142
Options exercised	0
Options forfeited / cancelled	(3,772)
Outstanding at ending	309,114	5,744
Exercisable Options	1,972
Weighted Average Exercise Price
Balance at the beginning (in dollars per share)	$ 636.74
Granted (in dollars per share)	17.50
Exercised (in dollars per share)	17.50
Exercised (in dollars per share)	0
Forfeited/Cancelled (in dollars per share)	0
Balance at the end (in dollars per share)	19.56	$ 636.74
Exercisable Options (in dollars per share)	$ 339.80
Weighted Average Contractual Terms
Contractual term (in years)	9 years 8 months 19 days	3 months 29 days
Options granted contractual term (in years)	9 years 9 months 10 days
Exercisable Options contractual term (in years)	3 months 29 days

STOCK BASED COMPENSATION - Exercise price range (Details)	6 Months Ended
	Jun. 30, 2022 $ / shares shares
Range of Exercise price
Outstanding Options	309,114
Exercisable Options	1,972
Exercise price $17.50
Range of Exercise price
Exercise Price, lower limit \| $ / shares	$ 17.50
Outstanding Options	307,142
Exercisable Options	0
Exercise price $339.80
Range of Exercise price
Exercise Price, upper limit \| $ / shares	$ 339.80
Outstanding Options	1,972
Exercisable Options	1,972

STOCK BASED COMPENSATION - Weighted average assumptions (Details)	6 Months Ended
	Jun. 30, 2022 $ / shares
STOCK BASED COMPENSATION
Expected volatility	106.00%
Risk-free interest rate	2.70%
Expected dividend yield	0.00%
Expected life of options in years	6 years 10 months 24 days
Exercise Price	$ 17.50
Fair value of common stock	15.38
Estimated fair value of option	$ 12.92

STOCK BASED COMPENSATION - Stock based compensation expense (Details)	3 Months Ended	6 Months Ended
	Jun. 30, 2022 USD ($)	Jun. 30, 2022 USD ($)
Stock-Based Compensation Expense
Total stock-based compensation expense		$ 229,000
Unrecognized stock compensation expense	$ 3,739,529	$ 3,739,529
Unrecognized stock compensation expense expected to be recognized over the remaining weighted average service period		3 years 7 months 6 days
Research and development
Stock-Based Compensation Expense
Total stock-based compensation expense	30,000	$ 30,000
General and administrative
Stock-Based Compensation Expense
Total stock-based compensation expense	$ 199,000	$ 199,000

PREPAID EXPENSES (Details) - USD ($)	Jun. 30, 2022	Dec. 31, 2021
PREPAID EXPENSES
Prepaid R&D costs	$ 552,159	$ 329,033
Prepaid insurance	273,676	684,191
Prepaid other expenses	968	2,250
Total	$ 826,803	$ 1,015,474

ACCRUED EXPENSES (Details) - USD ($)	Jun. 30, 2022	Dec. 31, 2021
ACCRUED EXPENSES
Research contract expenses (note 13)	$ 741,776	$ 193,537
Payroll	573,511	557,937
Payroll taxes	153,552	199,582
Investor relations firm fees (note 13)	140,000	584,000
Professional fees	213,228	144,377
Other expenses	42,727	5,976
Total	$ 1,864,794	$ 1,685,409

IN-LICENSED TECHNOLOGY - Polytherapeutics (Details) - Polytherapeutics - USD ($)		6 Months Ended	12 Months Ended
	Mar. 24, 2018	Jun. 30, 2022	Dec. 31, 2021
Asset acquisitions and in-licensed technology
Purchase price agreement	$ 40,833
Royalty payments, as a percent of net revenue	4.00%
Royalty payment period	10 years
Royalty payments with one generic product introduced, as a percent of net revenue		2.00%	4.00%
Royalty payments with two generic product introduced, as a percent of net revenue		0.00%	2.00%
Intellectual property repurchase price		$ 100,000

IN-LICENSED TECHNOLOGY - Skinvisible (Details) - Skinvisable - USD ($)	Oct. 17, 2019	Jun. 30, 2022	Dec. 31, 2021	Jul. 10, 2021	Jun. 26, 2021	Jan. 27, 2021	Dec. 31, 2019
Asset acquisitions and in-licensed technology
Purchase price agreement	$ 1,000,000
Clinical milestones		$ 7,500,000
Regulatory approval milestones		$ 15,000,000				$ 21,750,000
Installment payments							$ 500,000
License acquisition liability			$ 250,000
Amendment 3
Asset acquisitions and in-licensed technology
Clinical milestones						750,000
Regulatory approval milestones						$ 5,000,000
Amendment 5
Asset acquisitions and in-licensed technology
First payment					$ 107,500
Second payment				$ 250,000
Third payment			$ 250,000

INTANGIBLE ASSETS (Details) - USD ($)	Jun. 30, 2022	Dec. 31, 2021
Intangible assets
Total cost	$ 1,040,433	$ 1,040,433
Accumulated amortization	(283,850)	(231,829)
Net book value	756,583	808,604
Acquired technology - Polytherapeutics
Intangible assets
Total cost	40,433	40,433
Technology license - Skinvisible
Intangible assets
Total cost	$ 1,000,000	$ 1,000,000

INTANGIBLE ASSETS (Details) - USD ($)	3 Months Ended		6 Months Ended
INTANGIBLE ASSETS (Details) - USD ($)	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
INTANGIBLE ASSETS
Amortization of intangibles	$ 26,000	$ 26,000	$ 52,021	$ 52,022
Expected amortization expense
2022	52,000		52,000
2023	104,000		104,000
2024	104,000		104,000
2025	104,000		104,000
2026	104,000		104,000
Thereafter	$ 288,000		$ 288,000

RELATED PARTY TRANSACTIONS - Narrative (Details) - USD ($)		3 Months Ended		6 Months Ended
	Oct. 28, 2021	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Consulting expense
Related Party Transaction [Line Items]
Consulting expense from related party		$ 12,000	$ 0	$ 24,000	$ 0
Officers and Founders
Related Party Transaction [Line Items]
Payment of amounts due to officers		$ 150,000	$ 19,466	$ 300,000	$ 154,466
Monthly payment amounts due to related party	$ 25,000

RELATED PARTY TRANSACTIONS - Amounts due to officers (Details) - USD ($)	Jun. 30, 2022	Dec. 31, 2021
Related Party Transaction [Line Items]
Due to officers	$ 4,423,732	$ 4,723,732
Less: Short-term portion	(600,000)	(600,000)
Long-term portion	3,823,733	4,123,732
Salaries and allowances
Related Party Transaction [Line Items]
Due to officers	4,108,500	4,108,500
Invoices paid on behalf of the Company
Related Party Transaction [Line Items]
Due to officers	$ 315,232	$ 615,232

- Definition

Carrying amount as of the balance sheet date of obligations due all related parties. For classified balance sheets, represents the current portion of such liabilities (due within one year or within the normal operating cycle if longer).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(4)(iii)(C))
-URI http://asc.fasb.org/extlink&oid=124359900&loc=SL124442552-122756

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(5))
-URI http://asc.fasb.org/extlink&oid=124359900&loc=SL124442552-122756

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 850
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (d)
-URI http://asc.fasb.org/extlink&oid=6457730&loc=d3e39549-107864

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1A
-Subparagraph (SX 210.13-01(a)(4)(iv))
-URI http://asc.fasb.org/extlink&oid=124359900&loc=SL124442526-122756

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1A
-Subparagraph (SX 210.13-01(a)(4)(iii)(B))
-URI http://asc.fasb.org/extlink&oid=124359900&loc=SL124442526-122756

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1A
-Subparagraph (SX 210.13-01(a)(5))
-URI http://asc.fasb.org/extlink&oid=124359900&loc=SL124442526-122756

Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.19(a))
-URI http://asc.fasb.org/extlink&oid=120391452&loc=d3e13212-122682

Reference 8: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(k)(1))
-URI http://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 470
-SubTopic 10
-Section S99
-Paragraph 1B
-Subparagraph (SX 210.13-02(a)(4)(iv))
-URI http://asc.fasb.org/extlink&oid=124359900&loc=SL124442552-122756

+ Details

RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS - Research (Details)		1 Months Ended				3 Months Ended		6 Months Ended
	Jun. 30, 2022 USD ($)	Mar. 31, 2022 USD ($)	Nov. 30, 2020 USD ($)	Jul. 31, 2018 USD ($)	Jul. 31, 2018	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	May 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Nov. 30, 2021 USD ($)	Feb. 28, 2021 USD ($)
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Research and development						$ 726,694	$ 239,280	$ 1,314,263	$ 296,068
Accrued expenses	$ 1,864,794					1,864,794		1,864,794			$ 1,685,409
Other income							(3,360,653)	493,237	(6,462,763)
Prepaid R&D costs	552,159					552,159		552,159			329,033
Gain on reduction in liability								416,000
Research and consulting agreement \| Polytherapeutics
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Monthly payments													$ 20,833
Total amount of agreement													$ 666,667
Research and consulting agreement \| Axella Research LLC
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Number of agreements					3
Number of options to pay				270,000	2
Option 1, equity payment (as a percent)					0.50%
Option 1, cash payment (as a percent)					0.50%
Option 2, cash payment discount (as a percent)					20.00%
Research and development						0	0	0	0
Research and consulting agreement \| Netherton Syndrome
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Initial expenses	77,000					77,000		77,000
Research and consulting agreement \| Therapeutics Inc.
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Research and development						309,000	0	480,000	0
Research and consulting agreement \| Scleroderma
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Total amount of agreement										$ 610,000
Prepaid R&D costs										$ 220,000
Consulting agreements \| Netherton Syndrome
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Total amount of agreement												$ 250,000
Consulting agreements \| Therapeutics Inc.
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Total amount of agreement			$ 4,400,000
Initial term			3 years
Written termination notice period			90 days
Consulting agreements \| Investor Relations firm
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Monthly payments	14,000					14,000		14,000
Accrued expenses											$ 584,000
Other income		$ 416,000
Gain on reduction in liability	$ 140,000	$ 168,000
Consulting fees						$ 28,000	$ 42,000	$ 28,000	$ 42,000

RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS - Employment agreements (Details) - Employment Contracts [Member]		1 Months Ended	6 Months Ended
	Apr. 12, 2022 USD ($)	Nov. 30, 2021 USD ($)	Jun. 30, 2022 Y	Mar. 31, 2018 USD ($)
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Number founders under employment agreement	2			2
Two Founders
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Combine salary and benefits	$ 990,000			$ 996,000
Number of years of salary and bonus equivalent for termination \| Y			2
Annual target discretionary bonus (in percent)	45.00%
Chief Financial Officer
RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS
Transaction bonus		$ 360,000

RESEARCH, CONSULTING AGREEMENTS AND OTHER COMMITMENTS - Merger agreement commitment (Details)	6 Months Ended
	Jun. 30, 2022
RESEARCH, CONSULTING AGREEMENTS AND COMMITMENTS
Percentage of share capital held in Escrow by Altshuler Shaham Trusts Ltd.	40.00%

SHAREHOLDERS' EQUITY AND SHARE OWNERSHIP AND RIGHTS - Share Capital (Details)			1 Months Ended	3 Months Ended	6 Months Ended
	Oct. 28, 2021 shares	Mar. 05, 2018 USD ($) shares	May 31, 2022 shares	Jun. 30, 2022 Y Vote $ / shares shares	Jun. 30, 2022 Y Vote $ / shares shares	Aug. 01, 2022 shares	Apr. 12, 2022 $ / shares shares	Apr. 11, 2022 shares	Dec. 31, 2021 $ / shares shares
SHARE OWNERSHIP AND RIGHTS
Ordinary shares, shares authorized				50,000,000,000	50,000,000,000				50,000,000,000
Ordinary shares, par value \| $ / shares				$ 0	$ 0		$ 0		$ 0
Series B warrants
SHARE OWNERSHIP AND RIGHTS
Shares issued (in shares)				1,710,500,800
ADS \| Series B warrants
SHARE OWNERSHIP AND RIGHTS
Shares issued (in shares)				342,100
Number of ADS received for a warrant				1.0	1.0
Quoin
SHARE OWNERSHIP AND RIGHTS
Ordinary shares, shares authorized							50,000,000,000	12,500,000,000
Shares issued (in shares)		100
Shares issued, Value \| $		$ 100
Number of founders	2
Shares issued upon conversion	240,292		224,388
Number of vote for each ordinary share \| Vote				1	1
Number of years of income that limits distribution \| Y				2	2
Maximum period between date of financial statements and distribution date					6 months
Threshold period for not to enter in to an agreement for variable rate transaction from the date of closing of the Offering					180 days
Threshold period for not to issue or proposed issuance of any ADSs or ordinary shares					90 days
Quoin \| ADS
SHARE OWNERSHIP AND RIGHTS
Number of ordinary shares for each ADS						5,000

SHAREHOLDERS' EQUITY AND SHARE OWNERSHIP AND RIGHTS - Warrants (Details) - $ / shares	6 Months Ended	12 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
Weighted Average Exercise Price
Balance at the beginning (in dollars per share)	$ 55.39
Granted (in dollars per share)	49.75	$ 49.75
Weighted Average Exercise Price Assumed as part of Merger		137.50
Balance at the end (in dollars per share)	$ 50.49	$ 55.39
ADS
WARRANTS
Outstanding at beginning	137,283
Granted	1,257,721	128,463
Assumed as part of Merger		8,820
Exercised - cashless	(342,100)
Outstanding at ending	1,052,904	137,283

SHAREHOLDERS' EQUITY AND SHARE OWNERSHIP AND RIGHTS - Warrants and Options (Details)	Jun. 30, 2022 $ / shares shares
ADS
Equity
Outstanding warrants	1,052,904
Warrants \| 2020 note holders
Equity
Warrants, exercise price of warrants (in dollars per share) \| $ / shares	$ 49.75
Warrants \| 2020 note holders \| ADS
Equity
Outstanding warrants	29,388
Warrants \| Investor
Equity
Warrants, exercise price of warrants (in dollars per share) \| $ / shares	$ 49.75
Warrants \| Investor \| ADS
Equity
Outstanding warrants	99,074
Warrants \| Cellect warrantholders
Equity
Warrants, exercise price of warrants (in dollars per share) \| $ / shares	$ 137.50
Warrants \| Cellect warrantholders \| ADS
Equity
Outstanding warrants	8,820
Series A warrants held by Investor \| Investor
Equity
Warrants, exercise price of warrants (in dollars per share) \| $ / shares	$ 49.75
Series A warrants held by Investor \| Investor \| ADS
Equity
Outstanding warrants	533,274
Series B warrants \| Investor
Equity
Warrants, exercise price of warrants (in dollars per share) \| $ / shares	$ 49.75
Series B warrants \| Investor \| ADS
Equity
Outstanding warrants	191,174
Series C warrants \| ADS
Equity
Number issuable warrants	191,173
Series C warrants \| Investor
Equity
Warrants, exercise price of warrants (in dollars per share) \| $ / shares	$ 49.75
Series C warrants \| Investor \| ADS
Equity
Outstanding warrants	191,174

CONTINGENCIES (Details) - USD ($)			1 Months Ended
CONTINGENCIES (Details) - USD ($)	Aug. 12, 2022	Jun. 10, 2022	Feb. 29, 2020	Jun. 30, 2022	Apr. 22, 2022
CONTINGENCIES
Possible damages sought			$ 666,667
Minimum stockholders' equity to be maintained				$ 2,500,000	$ 2,500,000
Minimum bid price	$ 1.00	$ 1.00
Number of consecutive business days		30 days
Minimum consecutive business days to maintain closing bid price		10 days

LICENSE AGREEMENTS (Details)	1 Months Ended		6 Months Ended
LICENSE AGREEMENTS (Details)	Dec. 31, 2021 agreement	Nov. 30, 2021 agreement	Jun. 30, 2022 USD ($) agreement
LICENSE AGREEMENTS
Number of license and supply agreements entered \| agreement	3	3	5
Royalty revenues \| $			$ 0

SUBSEQUENT EVENTS (Details) - Subsequent Event $ / shares in Units, $ in Millions	Aug. 09, 2022 USD ($) $ / shares shares	Jul. 12, 2022 shares	Jul. 11, 2022 shares
Subsequent Event [Line Items]
Threshold period for not entering variable rate transaction from closing (in days)	180 days
Threshold period for to issue, enter into any agreement to issue or announce the issuance or proposed issuance of any ADSs or ordinary shares or their equivalents from closing (in days)	90 days
Offering
Subsequent Event [Line Items]
Shares issued (in shares)	11,050,000,000
ADS
Subsequent Event [Line Items]
Number of shares represented for one ADS		5,000	400
Ratio Change		12.5
ADS \| Offering
Subsequent Event [Line Items]
Shares issued (in shares)	2,210,000
Purchase price \| $ / shares	$ 5.00
Pre-Funded Warrants \| Offering
Subsequent Event [Line Items]
Warrants, number of securities called by warrants (in shares)	5,750,000,000
Pre-Funded Warrants \| ADS \| Offering
Subsequent Event [Line Items]
Purchase price \| $ / shares	$ 4.9999
Warrants, number of securities called by warrants (in shares)	1,150,000
Gross proceeds from offering \| $	$ 16.8
Net proceeds after deducting the placement agent's fees and estimated offering expenses from offering \| $	$ 15.0
Common Warrant \| ADS \| Offering
Subsequent Event [Line Items]
Warrants, exercise price of warrants (in dollars per share) \| $ / shares	$ 5.00

SUBSEQUENT EVENTS - Altium warrant exercises and the Altium Agreement, the warrants outstanding (Details) - $ / shares		1 Months Ended
	Aug. 19, 2022	Aug. 10, 2022	Aug. 02, 2022	Jul. 14, 2022	Jun. 30, 2022	Mar. 31, 2022	Dec. 31, 2021	Jun. 30, 2021	Mar. 31, 2021	Dec. 31, 2020
Subsequent Event [Line Items]
Number of shares outstanding					5,065,154,799		3,354,650,799
ADS
Subsequent Event [Line Items]
Number of shares outstanding					1,013,031	670,931	670,930	240,292	240,292	240,292
Number of warrants outstanding					1,052,904
ADS \| Warrants held by 2020 noteholders
Subsequent Event [Line Items]
Number of warrants outstanding					3,216
ADS \| Altium Agreement
Subsequent Event [Line Items]
Number of warrants outstanding					0
Subsequent Event
Subsequent Event [Line Items]
Number of shares outstanding	23,996,009,799
Subsequent Event \| ADS
Subsequent Event [Line Items]
Number of shares outstanding	4,799,129
Percentage of shares outstanding	99.99%
Subsequent Event \| ADS \| Altium Agreement
Subsequent Event [Line Items]
Exercise price of warrant per ADS			$ 0.00
Shares issued (in shares)			399,999
Number of warrants outstanding	3,372,036
Subsequent Event \| ADS \| Altium Agreement \| Series A Warrant and Investor Exchange Warrants
Subsequent Event [Line Items]
Number of shares issued for warrants				399,999
Exercise price of warrant per ADS				$ 0.00
Subsequent Event \| ADS \| Altium Agreement \| Warrants held by 2020 noteholders
Subsequent Event [Line Items]
Number of shares issued for warrants		26,172
Exercise price of warrant per ADS	$ 0	$ 0.00		$ 0.00
Shares issued (in shares)		26,172
Number of warrants outstanding	3,216
Subsequent Event \| ADS \| Altium Agreement \| Exchange warrant held by Investor
Subsequent Event [Line Items]
Number of shares issued for warrants			99,074
Subsequent Event \| ADS \| Altium Agreement \| Warrants held by former Cellect warrant holders
Subsequent Event [Line Items]
Exercise price of warrant per ADS	$ 137.5
Number of warrants outstanding	8,820
Subsequent Event \| ADS \| Altium Agreement \| Common Warrant
Subsequent Event [Line Items]
Exercise price of warrant per ADS	$ 5.00
Number of warrants outstanding	3,360,000
Subsequent Event \| ADS \| Altium Agreement \| Series A warrants held by Investor
Subsequent Event [Line Items]
Number of shares issued for warrants			300,925